Canonical and noncanonical Wnt pathway: A comparison among normal ovary, benign ovarian tumor and ovarian cancer

Canonical and noncanonical Wnt pathway: A comparison among normal ovary, benign ovarian tumor and ovarian cancer

Author Badiglian Filho, Levon Autor UNIFESP Google Scholar
Oshima, Celina Tizuko Fujiyama Autor UNIFESP Google Scholar
Lima, Flavio de Oliveira Autor UNIFESP Google Scholar
Costa, Henrique de Oliveira Autor UNIFESP Google Scholar
Damiao, Roberio de Sousa Autor UNIFESP Google Scholar
Gomes, Thiago Simao Autor UNIFESP Google Scholar
Goncalves, Wagner Jose Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The Wnt family is involved in tumorigenesis of several tissues. in ovarian cancer, the role played by Writs and its pathways is not clearly defined. in order to analyze the canonical and noncanonical Writ pathway in normal ovary, benign ovarian tumor and ovarian cancer, we evaluated the immunohistochemical expression of Wnt1, Frizzled-1 (FZD1), Wnt5a, Frizzled-5 (FZD5) and B-catenin. Ovarian specimens were obtained from surgeries performed between 1993 and 2004. the patients were divided in three groups: group A, epithelial ovarian cancer (n=38); group B, benign epithelial neoplasia (n=28); and group C, normal ovaries (n=26). Immunoreactivity for Wnt1, FZD1, Wnt5a, FZD5 and B-catenin was scored for each group. the proportion of Wnt1 positive women in group A (29.4%) was significantly higher than in group B (4.3%) and C (9.1%) (p=0.020). the proportion of FZD1 positive patients in group C (54.5%) was significantly lower than in group A (97.1%) and B (90.0%) (p<0.001). the proportion of Wnt5a positive women was significantly higher for group A (80.0%) compared to group B (25.0%) and C (27.3%) (p<0.001). the proportion of beta-catenin positive patients in group C (95.8%) was significantly higher than group B (52.4%) (p=0.004). Comparison of the survival curves in group A according to Wnt5a expression showed a significant difference between positive and negative patients, whereas the Wnt5a positive women showed worse results (p=0.050). Our findings suggest that the pathways related to Wnt5a have an important role in ovarian malignant neoplasia. Furthermore, Wnt5a was found to be a predictor of poor prognosis for ovarian cancer.
Keywords beta-catenin
Wnt5a
Wnt
Frizzled
ovarian cancer
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 06/51401-1
Date 2009-02-01
Published in Oncology Reports. Athens: Spandidos Publ Ltd, v. 21, n. 2, p. 313-320, 2009.
ISSN 1021-335X (Sherpa/Romeo, impact factor)
Publisher Spandidos Publ Ltd
Extent 313-320
Origin http://dx.doi.org/10.3892/or_00000223
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000262679300006
URI http://repositorio.unifesp.br/handle/11600/31273

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