The allergic sensitization in infants with atopic eczema from different countries

The allergic sensitization in infants with atopic eczema from different countries

Author Benedictis, F. M. de Google Scholar
Franceschini, F. Google Scholar
Hill, D. Google Scholar
Naspitz, C. Autor UNIFESP Google Scholar
Simons, F. E. R. Google Scholar
Wahn, U. Google Scholar
Warner, J. O. Google Scholar
Longueville, M. de Google Scholar
EPAAC Study Grp Google Scholar
Institution Salesi Childrens Hosp
Royal Childrens Hosp
Universidade Federal de São Paulo (UNIFESP)
Univ Manitoba
Univ Childrens Hosp Charite
Univ London Imperial Coll Sci Technol & Med
UCB
Abstract No study has compared allergic sensitization patterns in infants with atopic eczema from different countries. the aim of this study was to investigate the patterns of allergic sensitization in a cohort of infants with atopic eczema participating in a multicentre, international study.Two thousand one hundred and eighty-four infants (mean age 17.6 months) with atopic eczema from allergic families were screened in 94 centres in 12 countries to participate in a randomized trial for the early prevention of asthma. Clinical history, Severity Scoring of Atopic Dermatitis Index, measurements for total serum IgE and specific IgE antibodies to eight food and inhalant allergens were entered into a database before randomization to treatment. A history of type of feeding in the first weeks of life and exposure to animals was recorded.A total of 52.9% of the infants had raised total IgE, and 55.5% were sensitized to at least one allergen. There was a wide difference in the total IgE values and in the sensitization rates to foods and aeroallergens among infants from different countries. the highest prevalence rates of allergen-sensitized infants were found in Australia (83%), the UK (79%) and Italy (76%). Infants from Belgium and Poland consistently had the lowest sensitization rates. in each country, a characteristic pattern of sensitization was found for aeroallergens (house dust mite > cat > grass pollen > Alternaria), but not for food allergens.In infants with atopic eczema, there is a wide variation in the pattern of allergic sensitization between countries, and data from one country are not necessarily generalizable to other countries.
Keywords atopy
eczema
infants
sensitization
Language English
Sponsor UCB
Date 2009-02-01
Published in Allergy. Malden: Wiley-Blackwell Publishing, Inc, v. 64, n. 2, p. 295-303, 2009.
ISSN 0105-4538 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 295-303
Origin http://dx.doi.org/10.1111/j.1398-9995.2008.01779.x
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000262634000018
URI http://repositorio.unifesp.br/handle/11600/31269

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