Insulin resistance and not steatosis is associated with modifications in oxidative stress markers in chronic hepatitis C, non-3 genotype

Insulin resistance and not steatosis is associated with modifications in oxidative stress markers in chronic hepatitis C, non-3 genotype

Author Oliveira, Ana C. Autor UNIFESP Google Scholar
Parise, Edison Roberto Autor UNIFESP Google Scholar
Catarino, Regina M. Autor UNIFESP Google Scholar
Lanzoni, Valeria Pereira Autor UNIFESP Google Scholar
Leite-Mór, Marilisa Moraes Barros Autor UNIFESP Google Scholar
Simon, Karin Argenti Autor UNIFESP Google Scholar
Junqueira, Virginia B. C. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background: Modifications of oxidative stress are reported in hepatitis C. the relationship between insulin resistance (IR), steatosis and oxidative stress is not established. Materials and methods: One hundred and eighty-seven HCV-RNA patients were assessed by determination of biochemical, metabolic and viral features, HOMA-IR and morphological alterations. in the 52-non-3 genotypes sub-group and 35 healthy individuals, thiobarbituric acid (TBARS), total glutathione (total-GSH), vitamins C and E, lycopene, beta-carotene, glutathione peroxidase (GPx), catalase and superoxide dismutase were determined. Results: in non-3 genotype patients, steatosis was associated with higher values of BMI, HOMA-IR and triglycerides. in the 52-HCV sub-group, values of TBARS, GPx and total-GSH differ from the control group. Despite these, differences could not be observed according to the presence of steatosis, patients with IR presented significant differences regarding total-GSH (p = 0.019), beta-carotene (p = 0.006), lycopene (p = 0.005) and GPx (p = 0.009). Conclusion: in non-3 genotype HCV carries, IR, and not steatosis, is associated with modifications in serum levels of oxidative stress.
Keywords Insulin resistance
chronic hepatitis C
hepatic steatosis
oxidative stress markers
fibrosis
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 02/05260-6
Date 2009-01-01
Published in Free Radical Research. Abingdon: Taylor & Francis Ltd, v. 43, n. 12, p. 1187-1194, 2009.
ISSN 1071-5762 (Sherpa/Romeo, impact factor)
Publisher Taylor & Francis Ltd
Extent 1187-1194
Origin http://dx.doi.org/10.3109/10715760903247249
Access rights Closed access
Type Article
Web of Science ID WOS:000272753100005
URI http://repositorio.unifesp.br/handle/11600/31239

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