Comparable efficacy and tolerability between twice daily and three times daily betahistine for Meniere's disease

Comparable efficacy and tolerability between twice daily and three times daily betahistine for Meniere's disease

Author Ganança, Mauricio Malavasi Autor UNIFESP Google Scholar
Caovilla, Heloisa Helena Autor UNIFESP Google Scholar
Ganança, Fernando Freitas Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Bandeirante São Paulo
Abstract Conclusion. Betahistine at oral doses of 16 mg tid and 24 mg bid provides similar efficacy and tolerability in the treatment of vertigo in patients with Meniere's disease. Objective. To compare the efficacy and tolerability of betahistine 16 mg tid and 24 mg bid in the treatment of vertigo in patients with Meniere's disease. Patients and methods. This was a randomized, open-label study of 120 consecutive patients with well-established Meniere's disease treated with betahistine 16 mg tid or 24 mg bid for 24 weeks. Treatment efficacy, assessed by clinical outcome level in terms of severity, frequency and duration of vertigo spells, was evaluated at baseline and at weeks 4, 12 and 24. Between-group comparisons of outcome data (Wilcoxon, Mann-Whitney U test) and adverse events (chi-squared test) were made. Results. Betahistine 16 mg tid or 24 mg bid showed a significant improvement in clinical outcome level from baseline to week 24 (p0.01). There was no significant difference between dosage groups regarding improvement in vertigo at any time point during the study. There was no significant difference between groups in the incidence of adverse events, which was low (maximum: headache, 16 mg tid, 16.7% of patients at week 4; 6.7% at week 24). the number of patients reporting adverse events diminished with time.
Keywords Vertigo
tinnitus
hearing impairment
histamine
treatment
pharmacotherapy
dosing frequency
adherence
Language English
Date 2009-01-01
Published in Acta Oto-laryngologica. Oslo: Taylor & Francis As, v. 129, n. 5, p. 487-492, 2009.
ISSN 0001-6489 (Sherpa/Romeo, impact factor)
Publisher Taylor & Francis As
Extent 487-492
Origin http://dx.doi.org/10.1080/00016480802273082
Access rights Closed access
Type Article
Web of Science ID WOS:000265273200003
URI http://repositorio.unifesp.br/handle/11600/31184

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