Old mice present increased levels of succinate dehydrogenase activity and lower vulnerability to dyskinetic effects of 3-nitropropionic acid

Old mice present increased levels of succinate dehydrogenase activity and lower vulnerability to dyskinetic effects of 3-nitropropionic acid

Author Rosenstock, T. R. Autor UNIFESP Google Scholar
Abilio, V. C. Autor UNIFESP Google Scholar
Frussa-Filho, R. Autor UNIFESP Google Scholar
Kiyomoto, B. H. Autor UNIFESP Google Scholar
Smaili, Soraya Soubhi Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Huntington's disease (HD) is a neurodegenerative disorder, with an age-related onset and a progressive development, characterized by choreiform movements. 3-Nitropropionic acid (3NP) induces the inhibition of succinate dehydrogenase (SDH), an increase in oxidative stress and anatomic changes that are related to the pathophysiology of HD. Hence, this toxin is a useful tool to study this pathology. This study compares the effects of 3NP on the development of orofacial dyskinesia (OD) and on SDH activity in Young and old mice. Treatment with 3NP (5. 10, 15 or 20 mg/kg once a day, for four days) induced OD in young mice. Old mice presented an increase in the basal level of orofacial movement that was not potentiated by any dose of 3NP. Histochemical analyses showed that old mice presented an increase in the SDH activity. Finally, 3NP induced a decrease in SDH activity at both ages. We Suggest that the 3NP-induced OD in Young mice is related to the inhibition of SDH activity. in parallel, an enhancement in the basal activity of SDH could be related to the absence of a further increase in the OD presented by old mice treated with 3NP. (c) 2008 Elsevier Inc. All rights reserved.
Keywords Huntington's disease
3-Nitropropionic acid
Oxidative stress
Aging
Succinate dehydrogenase
Orofacial dyskinesia
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2009-01-01
Published in Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 91, n. 3, p. 327-332, 2009.
ISSN 0091-3057 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 327-332
Origin http://dx.doi.org/10.1016/j.pbb.2008.08.011
Access rights Closed access
Type Article
Web of Science ID WOS:000263014500010
URI http://repositorio.unifesp.br/handle/11600/31170

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