Comparison of carbamazepine and lithium in treatment of birolar disorder: a systematic review of randomized controlled trials

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dc.contributor.author Ceron-Litvoc, Daniela [UNIFESP]
dc.contributor.author Soares, Bernardo Garcia [UNIFESP]
dc.contributor.author Geddes, John
dc.contributor.author Litvoc, Julio
dc.contributor.author Lima, Mauricio Silva de [UNIFESP]
dc.date.accessioned 2016-01-24T13:52:02Z
dc.date.available 2016-01-24T13:52:02Z
dc.date.issued 2009-01-01
dc.identifier http://dx.doi.org/10.1002/hup.990
dc.identifier.citation Human Psychopharmacology-clinical and Experimental. Chichester: John Wiley & Sons Ltd, v. 24, n. 1, p. 19-28, 2009.
dc.identifier.issn 0885-6222
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/31143
dc.description.abstract Objectives To review data from randomized controlled trials (RCTs) assessing the comparative efficacy of carbamazepine and lithium in treatment of acute manic and maintenance phase of bipolar disorder (BD).Design RCTs were identified through a search strategy that included: electronic databases, reference cross-checking, hand search of non-indexed publications. and book chapters on the treatment of BD comparing carbamazepine with lithium. Outcomes investigated were antimanic effect. trial withdrawal, relapse, hospitalization, need for rescue medication, and presence of adverse effects. Selection of studies and data analysis were performed independently by authors. Whenever possible, data from trials were combined through meta-analyses. Relative risks (RR) were estimated for dichotomous data.Results in acute mania. carbamazepine was similar to lithium oil the following Outcomes: trial withdrawal due to adverse effects, number of participants with at least one adverse effect. improvement in the Clinical Global Impression (CGI). in acute mania, carbamazepine was associated with fewer trial withdrawals. in maintenance treatment. carbamazepine was similar to lithium in relapses and hospitalization. but there were fewer trial withdrawals due to adverse effects on lithium.Conclusion This review suggests that carbamazepine might be comparable to lithium in terms of efficacy and safety. and therefore it valuable option in the treatment of both manic and maintenance phases. Copyright (c) 2008 John Wiley & Sons, Ltd. en
dc.format.extent 19-28
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Human Psychopharmacology-clinical and Experimental
dc.rights Acesso restrito
dc.subject carbamzepine en
dc.subject lithium en
dc.subject bipolar en
dc.subject mood disorder en
dc.subject review en
dc.title Comparison of carbamazepine and lithium in treatment of birolar disorder: a systematic review of randomized controlled trials en
dc.type Resenha
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Univ Oxford
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.description.affiliation Univ Oxford, Dept Psychiat, Oxford OX1 2JD, England
dc.description.affiliation Univ São Paulo, Coll Med, BR-05508 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.identifier.doi 10.1002/hup.990
dc.description.source Web of Science
dc.identifier.wos WOS:000262707100002



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