Gamma ventral capsulotomy for treatment of resistant obsessive-compulsive disorder: A structural MRI pilot prospective study

Gamma ventral capsulotomy for treatment of resistant obsessive-compulsive disorder: A structural MRI pilot prospective study

Author Cecconia, Janaina Philippi Google Scholar
Lopes, Antonio Carlos Google Scholar
Duran, Fabio Luis de Souza Google Scholar
Santos, Luciana Cristina Google Scholar
Hoexter, Marcelo Queiroz Autor UNIFESP Google Scholar
Gentil, Andre Felix Google Scholar
Canteras, Miguel Montes Google Scholar
Castro, Claudio Campi de Google Scholar
Noren, George Google Scholar
Greenberg, Benjamin D. Google Scholar
Rauch, Scott L. Google Scholar
Busatto, Geraldo F. Google Scholar
Miguel, Euripedes Constantino Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Hosp Santa Paula
Brown Univ
Harvard Univ
Massachusetts Gen Hosp
Abstract Objective: the purpose of this study was to investigate regional structural abnormalities in the brains of five patients with refractory obsessive-compulsive disorder (OCD) submitted to gamma ventral capsulotomy. Methods: We acquired morphometric magnetic resonance imaging (MRI) data before and after 1 year of radiosurgery using a 1.5-T MRI scanner. Images were spatially normalized and segmented using optimized voxel-based morphometry (VBM) methods. Voxelwise statistical comparisons between pre- and post-surgery MRI scans were performed using a general linear model. Findings in regions predicted a priori to show volumetric changes (orbitofrontal cortex, anterior cingulate gyrus, basal ganglia and thalamus) were reported as significant if surpassing a statistical threshold of p<0.001 (uncorrected for multiple comparisons). Results: We detected a significant regional postoperative increase in gray matter volume in the right inferior frontal gyri (Brodmann area 47, BA47) when comparing all patients pre and postoperatively. Conclusions: Our results support the current theory of frontal-striatal-thalamic-cortical (FSTC) circuitry involvement in OCD pathogenesis. Gamma ventral capsulotomy is associated with neurobiological changes in the inferior orbitofrontal cortex in refractory OCD patients. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
Keywords Obsessive-compulsive disorder (OCD)
Magnetic resonance imaging (MRI)
Voxel-based morphometry
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Cientifico a Tecnologico
Grant number FAPESP: 1999/08560-6
FAPESP: 2005/55628-08
Conselho Nacional de Desenvolvimento Cientifico a Tecnologico: 305548/2005-0
Date 2008-12-12
Published in Neuroscience Letters. Clare: Elsevier B.V., v. 447, n. 2-3, p. 138-142, 2008.
ISSN 0304-3940 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 138-142
Access rights Closed access
Type Article
Web of Science ID WOS:000261549300009

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