Low-level laser therapy improves bone repair in rats treated with anti-inflammatory drugs

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dc.contributor.author Ribeiro, D. A. [UNIFESP]
dc.contributor.author Matsumoto, M. A.
dc.date.accessioned 2016-01-24T13:51:58Z
dc.date.available 2016-01-24T13:51:58Z
dc.date.issued 2008-12-01
dc.identifier http://dx.doi.org/10.1111/j.1365-2842.2008.01891.x
dc.identifier.citation Journal of Oral Rehabilitation. Malden: Wiley-Blackwell, v. 35, n. 12, p. 925-933, 2008.
dc.identifier.issn 0305-182X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/31089
dc.description.abstract Nowadays, selective cyclooxygenase-2 non-steroidal anti-inflammatory drugs have been largely used in surgical practice for reducing oedema and pain. However, the association between these drugs and laser therapy is not known up to now. Herein, the aim of this study was to evaluate the action of anti-COX-2 selective drug (celecoxib) on bone repair associated with laser therapy. A total of 64 rats underwent surgical bone defects in their tibias, being randomly distributed into four groups: Group 1) negative control; Group 2) animals treated with celecoxib; Group 3) animals treated with low-level power laser and Group 4) animals treated with celecoxib and low-level power laser. the animals were killed after 48 h, 7, 14 and 21 days. the tibias were removed for morphological, morphometric and immunohistochemistry analysis for COX-2. Statistical significant differences (P < 0.05) were observed in the quality of bone repair and quantity of formed bone between groups at 14 days after surgery for Groups 3 and 4. COX-2 immunoreactivity was more intense in bone cells for intermediate periods evaluated in the laser-exposed groups. Taken together, such results suggest that low-level laser therapy is able to improve bone repair in the tibia of rats as a result of an up-regulation for cyclooxygenase-2 expression in bone cells. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 925-933
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Journal of Oral Rehabilitation
dc.rights Acesso restrito
dc.subject cyclooxygenase-2 en
dc.subject immunohistochemistry en
dc.subject rats en
dc.subject bone repair en
dc.subject low-level power laser en
dc.title Low-level laser therapy improves bone repair in rats treated with anti-inflammatory drugs en
dc.type Artigo
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Biosci, BR-11060001 Santos, SP, Brazil
dc.description.affiliation Univ Sagrado Coracao, Sch Dent, Dept Oral Maxillofacial Surg, USC, Bauru, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Biosci, BR-11060001 Santos, SP, Brazil
dc.description.sponsorshipID FAPESP: 04/09748-9
dc.identifier.doi 10.1111/j.1365-2842.2008.01891.x
dc.description.source Web of Science
dc.identifier.wos WOS:000261065500007



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