Low-level laser therapy improves bone repair in rats treated with anti-inflammatory drugs

Low-level laser therapy improves bone repair in rats treated with anti-inflammatory drugs

Autor Ribeiro, D. A. Autor UNIFESP Google Scholar
Matsumoto, M. A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo Nowadays, selective cyclooxygenase-2 non-steroidal anti-inflammatory drugs have been largely used in surgical practice for reducing oedema and pain. However, the association between these drugs and laser therapy is not known up to now. Herein, the aim of this study was to evaluate the action of anti-COX-2 selective drug (celecoxib) on bone repair associated with laser therapy. A total of 64 rats underwent surgical bone defects in their tibias, being randomly distributed into four groups: Group 1) negative control; Group 2) animals treated with celecoxib; Group 3) animals treated with low-level power laser and Group 4) animals treated with celecoxib and low-level power laser. the animals were killed after 48 h, 7, 14 and 21 days. the tibias were removed for morphological, morphometric and immunohistochemistry analysis for COX-2. Statistical significant differences (P < 0.05) were observed in the quality of bone repair and quantity of formed bone between groups at 14 days after surgery for Groups 3 and 4. COX-2 immunoreactivity was more intense in bone cells for intermediate periods evaluated in the laser-exposed groups. Taken together, such results suggest that low-level laser therapy is able to improve bone repair in the tibia of rats as a result of an up-regulation for cyclooxygenase-2 expression in bone cells.
Palavra-chave cyclooxygenase-2
immunohistochemistry
rats
bone repair
low-level power laser
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Número do financiamento FAPESP: 04/09748-9
Data de publicação 2008-12-01
Publicado em Journal of Oral Rehabilitation. Malden: Wiley-Blackwell, v. 35, n. 12, p. 925-933, 2008.
ISSN 0305-182X (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 925-933
Fonte http://dx.doi.org/10.1111/j.1365-2842.2008.01891.x
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000261065500007
Endereço permanente http://repositorio.unifesp.br/handle/11600/31089

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