Effects of Urinary Tract Infection in Patients With Bladder Augmentation and Kidney Transplantation

Effects of Urinary Tract Infection in Patients With Bladder Augmentation and Kidney Transplantation

Autor Pereira, Daniel Alcantara Autor UNIFESP Google Scholar
Barroso, Ubirajara Autor UNIFESP Google Scholar
Machado, Paula Autor UNIFESP Google Scholar
Medina Pestana, Jose Osmar Autor UNIFESP Google Scholar
Rosito, Thiago Elias Autor UNIFESP Google Scholar
Pires, Jesus Autor UNIFESP Google Scholar
Almeida, Claudio Autor UNIFESP Google Scholar
Ortiz, Valdemar Autor UNIFESP Google Scholar
Macedo, Antonio Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Purpose: We evaluated the rate of function decline of the renal allograft, in patients with augmented bladder. We also evaluated the prevalence of asymptomatic bacteriuria and urinary tract infection in these patients, and to demonstrate if these findings are predictors of allograft function decline, comparing children who underwent bladder augmentation with a control group.Materials and Methods: Among 170 children and adolescents undergoing renal transplantation at our institution 23 (14%) had previously undergone bladder augmentation. These patients were retrospectively compared (1:2 ratio) to 42 controls matched for gender, age, race, donor type, weight and immunosuppression protocol. the type of donor (living or cadaver), rate of acute tubular necrosis and cold ischemia time during transplantation were also similar between groups.Results: Mean followup was 18.0 +/- 13.9 months and 25.2 +/- 14.1 months for the augmented and nonaugmented bladder groups, respectively (p >0.05). the incidence of acute rejection within the first 12 months of kidney transplantation was 9% in the bladder augmentation group and 26% in controls (p >0.05). the rate of urinary tract infection or asymptomatic bacteriuria in the first 12 months after kidney transplantation was higher in the bladder augmentation group (19 patients, 83%) compared to controls (7 patients, 17%, p <0.001). Patients with augmented bladder had a higher number of hospital admissions (14 patients, 61%) compared to the control group (12 patients, 29%, p = 0.004). Despite the higher incidence of urinary tract infection in the augmented bladder group, there was no statistically significant difference in graft function between the groups at 6 months (1.1 +/- 0.3 mg/dl vs 1.0 +/- 0.3 mg/dl) or 12 months (1.0 +/- 0.2 mg/dl vs 1.2 +/- 0.7 mg/dl) after transplantation.Conclusions: Our study demonstrated that patients with transplanted kidney and augmented bladder had more asymptomatic bacteriuria and urinary tract infections than those without bladder augmentation. However, the rate of graft survival was similar between the groups.
Palavra-chave child
kidney transplantation
urinary bladder, neurogenic
urinary tract infections
Idioma Inglês
Data de publicação 2008-12-01
Publicado em Journal of Urology. New York: Elsevier B.V., v. 180, n. 6, p. 2607-2610, 2008.
ISSN 0022-5347 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 2607-2610
Fonte http://dx.doi.org/10.1016/j.juro.2008.08.049
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000260982200085
Endereço permanente http://repositorio.unifesp.br/handle/11600/31078

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