Intraocular Inflammation Associated with Ocular Toxoplasmosis: Relationships at Initial Examination

Intraocular Inflammation Associated with Ocular Toxoplasmosis: Relationships at Initial Examination

Autor Dodds, Emilio M. Google Scholar
Holland, Gary N. Google Scholar
Stanford, Miles R. Google Scholar
Yu, Fei Google Scholar
Siu, Willie O. Google Scholar
Shah, Kayur H. Google Scholar
Loon, Ninette Ten Dam-Van Google Scholar
Muccioli, Cristina Autor UNIFESP Google Scholar
Hovakimyan, Anna Google Scholar
Barisani-Asenbauer, Talin Google Scholar
Int Ocular Toxoplasmosis Res Grp Google Scholar
Instituição Consultores Oftalmol
Univ Calif Los Angeles
Kings Coll London
Univ Med Ctr
Universidade Federal de São Paulo (UNIFESP)
Univ Calif San Francisco
Med Univ Vienna
Malayan Eye Inst
Resumo PURPOSE: To describe characteristics of intraocular inflammation in eyes with active ocular toxoplasmosis and to identify relationships between signs of inflammation, complications (including elevated intraocular pressure [IOP]), other disease features, and host characteristics.DESIGN: Multicenter, retrospective, cross-sectional study.METHODS: We reviewed the medical records of 210 patients with toxoplasmic retinochoroiditis at seven in ternational sites (North America, South America, and Europe) for information from the first examination at each site during which patients had active retinal lesions. Signs of inflammation included anterior chamber (AC) cells and flare and vitreous humor cells and haze. Retinal lesion characteristics included size (<= 1 disc area [DA] or >1 DA) and presence or absence of macular involvement.RESULTS: AC cells and flare were related to vitreous inflammatory reactions (P <= .041). One or more signs of increased inflammation were related to the following factors: older patient age, larger retinal lesions, and extramacular location. in 30% of involved eyes, there was evidence of elevated IOP (despite use of glaucoma medications by some patients); other complications were uncommon. IOP of more than 21 mm Hg was associated with both increased AC cells and elevated flare (both P <= .001) and with macular involvement (P = .009). Inflammation seemed to be more severe among patients in Brazil than among those at other sites.CONCLUSIONS: There is substantial variation between patients in the severity of intraocular inflammation associated with ocular toxoplasmosis, attributable to multiple host and disease-related factors. Results suggest that disease characteristics also vary in different areas of the world. Elevated IOP at initial examination reflects the severity of inflammation. (Am J Ophthalmol 2008;146:856-865. (C) 2008 by Elsevier Inc. All rights reserved.)
Idioma Inglês
Financiador RESEARCH TO PREVENT BLINDNESS INC, NEW YORK, NEW YORK
JULES Stein Eye Institute
Skirball Foundation, New York, New York
Heed Foundation, Chicago, Illinois
Emily Plumb Estate and Trust
Data de publicação 2008-12-01
Publicado em American Journal of Ophthalmology. New York: Elsevier B.V., v. 146, n. 6, p. 856-865, 2008.
ISSN 0002-9394 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 856-865
Fonte http://dx.doi.org/10.1016/j.ajo.2008.09.006
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000261349200010
Endereço permanente http://repositorio.unifesp.br/handle/11600/31066

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