Meta-Analysis of the Symptom Structure of Obsessive-Compulsive Disorder

Meta-Analysis of the Symptom Structure of Obsessive-Compulsive Disorder

Autor Bloch, Michael H. Google Scholar
Landeros-Weisenberger, Angeli Google Scholar
Rosario-Campos, Maria Conceicao do Autor UNIFESP Google Scholar
Pittenger, Christopher Google Scholar
Leckman, James F. Google Scholar
Instituição Yale Univ
Universidade Federal de São Paulo (UNIFESP)
Resumo Objective: OCD is a clinically heterogeneous condition. This heterogeneity has the potential to reduce power in genetic, neuroimaging, and clinical trials. Despite a mounting number of studies, there remains debate regarding the exact factor structure of OCD symptoms. the authors conducted a meta-analysis to determine the factor structure of the Yale-Brown Obsessive Compulsive Scale Symptom Checklist.Method: Studies were included if they involved subjects with OCD and included an exploratory factor analysis of the 13 Yale-Brown Obsessive Compulsive Scale Symptom Checklist categories or the items therein. A varimax-rotation was conducted in SAS 9.1 using the PROC FACTOR CORR to extract factors from sample-size weighted co-occurrence matrices. Stratified meta-analysis was conducted to determine the factor structure of OCD in studies involving children and adults separately.Results: Twenty-one studies involving 5,124 participants were included. the four factors generated were 1) symmetry: symmetry obsessions and repeating, ordering, and counting compulsions; 2) forbidden thoughts: aggression, sexual, religious, and somatic obsessions and checking compulsions, 3) cleaning: cleaning and contamination, and 4) hoarding: hoarding obsessions and compulsions. Factor analysis of studies including adults yielded an identical factor structure compared to the overall meta-analysis. Factor analysis of child-only studies differed in that checking loaded highest on the symmetry factor and somatic obsessions, on the cleaning factor.Conclusions: A four-factor structure explained a large proportion of the heterogeneity in the clinical symptoms of OCD. Further item-level factor analyses are needed to determine the appropriate placement of miscellaneous somatic and checking OCD symptoms.
Idioma Inglês
Financiador NIMH
NIH Loan Repayment Program
Tourette's Syndrome Association
Doris Duke Charitable Foundation
APA/Janssen Research Scholars Program
AA-CAP Pilot Research
Número do financiamento NIMH: K05 MH-076273
Data de publicação 2008-12-01
Publicado em American Journal of Psychiatry. Arlington: Amer Psychiatric Publishing, Inc, v. 165, n. 12, p. 1532-1542, 2008.
ISSN 0002-953X (Sherpa/Romeo, fator de impacto)
Publicador Amer Psychiatric Publishing, Inc
Extensão 1532-1542
Direito de acesso Acesso aberto Open Access
Tipo Resenha
Web of Science WOS:000261266000010
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