Intron 1 and exon 1 alpha estrogen receptor gene polymorphisms in women with endometriosis

Intron 1 and exon 1 alpha estrogen receptor gene polymorphisms in women with endometriosis

Autor Sato, Helio Autor UNIFESP Google Scholar
Nogueira-de-Souza, Naiara C. Autor UNIFESP Google Scholar
D'Amora, Paulo Autor UNIFESP Google Scholar
Silva, Ismael D. C. G. Autor UNIFESP Google Scholar
Girao, Manoel J. B. C. Autor UNIFESP Google Scholar
Schor, Eduardo Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Objective: To evaluate the association of intron 1 and exon 1 polymorphisms in the estrogen receptor a gene (ER-alpha) with endometriosis in women.Design: Association study.Setting: Endometriosis Unit, Federal University of São Paulo.Patient(s): the control group consisted of volunteers older than 45 years who had no evidence of endometriosis antecedents. Two groups with the disease were evaluated: the first group had stage I or 11 endometriosis and the second group stage III or IV.Intervention(s): Polymerase chain reaction (PCR) followed by digestion with HaeIII and MspI endonucleases (RFLP) were applied to detect intron I and exon I polymorphisms, respectively, in a total of 125 controls and 105 affected women.Main Outcome Measure(s): Frequency and distribution of HaeIII and MspI polymorphisms in ER-alpha.Result(s): No significant differences in the frequency of polymorphisms either in intron I or exon I of ER-alpha were found when endometriosis patients were compared with control subjects. Furthermore. the frequency of ER-a polymorphisms within the two different groups of patients with disease was statistically similar. the odds ratio between presence of intron I single-nucleotide polymorphisms (SNP) and endometriosis was 0.904, and the odds ratio between exon I SNP and endometriosis was 0.976.Conclusion(S): the evaluated polymorphisms were not associated with endometriosis. (Fertil Steril(R) 2008; 90:2086-90. (C) 2008 by American Society for Reproductive Medicine.)
Palavra-chave Endometriosis/pathophysiology
endometriosis/genetics
estrogen receptor alpha/genetics
Idioma Inglês
Data de publicação 2008-12-01
Publicado em Fertility and Sterility. New York: Elsevier B.V., v. 90, n. 6, p. 2086-2090, 2008.
ISSN 0015-0282 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 2086-2090
Fonte http://dx.doi.org/10.1016/j.fertnstert.2007.10.023
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000261566800007
Endereço permanente http://repositorio.unifesp.br/handle/11600/31048

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