Selective regimes and evolutionary rates of HIV-1 subtype B V3 variants in the Brazilian epidemic

Selective regimes and evolutionary rates of HIV-1 subtype B V3 variants in the Brazilian epidemic

Author Diaz, Ricardo Sobhie Autor UNIFESP Google Scholar
Leal, Elcio de Souza Autor UNIFESP Google Scholar
Sanabani, Sabri Autor UNIFESP Google Scholar
Sucupira, Maria Cecília Araripe Autor UNIFESP Google Scholar
Tanuri, Amilcar Google Scholar
Sabino, Ester Cerdeira Autor UNIFESP Google Scholar
Janini, Luiz Mário Ramos Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Hemoctr São Paulo
Universidade Federal do Rio de Janeiro (UFRJ)
Abstract Half of subtype B Brazilian HIV-1 harbors the V3 tip GWGR instead of the GPGR. To investigate the evolution of GW variants, we analyzed 81 env sequences and 5 full-length GW genomes from antiretroviral-naive individuals sampled between 1983 and 1999. Phylogenetic analysis indicated that GW strains intermingle in the tree with other subtype B sequences. the mean d(N)/d(S) values of GW strains were Proximal to those of the other sequences, regardless of sampling years of clinical status. in sequences from patients with CD4+ T cell counts >= 200 cells/mu L, the mean d(N)/d(S) ratio was greater than one, suggesting a positive selection. the prevalence of GW variants was lower among individuals in whom disease progressed. This is probably attributable to the fact that tryptophan is replaced by other amino acids over time, whereas the GP motif does not evolve as rapidly. (C) 2008 Elsevier Inc. All rights reserved.
Keywords HIV-1 selective regimes
Genetic diversity
V3 envelop region
Clade B
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 98/14381-4
Date 2008-11-25
Published in Virology. San Diego: Academic Press Inc Elsevier Science, v. 381, n. 2, p. 184-193, 2008.
ISSN 0042-6822 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 184-193
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000260841500005

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