Serum amyloid A induces CCL20 secretion in mononuclear cells through MAPK (p38 and ERK1/2) signaling pathways

Serum amyloid A induces CCL20 secretion in mononuclear cells through MAPK (p38 and ERK1/2) signaling pathways

Author Sandri, Silvana Google Scholar
Hatanaka, Elaine Google Scholar
Franco, Andressa G. Google Scholar
Pedrosa, Alziana M. C. Google Scholar
Monteiro, Hugo P. Autor UNIFESP Google Scholar
Campa, Ana Google Scholar
Institution Universidade de São Paulo (USP)
Univ Cruzeiro
Universidade Federal de São Paulo (UNIFESP)
Abstract Although the serum levels of SAA had been reported to be upregulated during inflammatory/infectious process, the role of this acute-phase protein has not been completely elucidated. in previous studies, we demonstrated that SAA stimulated the production of TNF-alpha, IL-1 beta, IL-8, NO, and ROS by neutrophils and/or mononuclear cells. Herein we demonstrate that SAA induces the expression and release of CCL20 from Cultured human blood mononuclear cells. We also focus on the signaling pathways triggered by SAA. in THP-1 cells SAA promotes phosphorylation of p38 and ERK1/2. Furthermore, the addition of SB203580 (p38 inhibitor) and PD98059 (ERK 1/2 inhibitor) inhibits the expression and release of CCL20 in mononuclear cells treated with SAA. Our results point to SAA as an important link of innate to adaptive immunity, once it might act on the recruitment of mononuclear cells. (C) 2008 Elsevier B.V. All rights reserved.
Keywords CCL20
Mononuclear cells and serum amyloid A (SAA)
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2008-11-16
Published in Immunology Letters. Amsterdam: Elsevier B.V., v. 121, n. 1, p. 22-26, 2008.
ISSN 0165-2478 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 22-26
Access rights Closed access
Type Article
Web of Science ID WOS:000261280600004

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