Casein kinase I epsilon (CKI epsilon) N408 allele is very rare in the Brazilian population and is not involved in susceptibility to circadian rhythm sleep disorders

Casein kinase I epsilon (CKI epsilon) N408 allele is very rare in the Brazilian population and is not involved in susceptibility to circadian rhythm sleep disorders

Autor Castro, Rosa M. R. P. S. Autor UNIFESP Google Scholar
Barbosa, Ana A. Autor UNIFESP Google Scholar
Pedrazzoli, Mario Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Circadian rhythms are regulated by clock proteins through post-translational modifications. Indeed, Casein kinase I epsilon (CKI epsilon) promotes reversible phosphorylation of PER proteins, and a deficiency in this phosphorylation has been implicated in human sleep disorders. Here, we investigated the CKI epsilon S408N polymorphism in a Brazilian population sample. the N408 allele was previously described to be much less frequent in individuals with Delayed Sleep-Phase Syndrome (DSPS), than in the general Japanese population, Suggesting a protective function for the allele against the disease. We found that this polymorphism is very rare in the Brazilian population (1.37%), indicating that it has no influence on susceptibility to circadian rhythm sleep disorders. Therefore, it is necessary to account for adaptative influences in genetic background, analyzing different groups with different photoperiods, to validate the effects of this and other polymorphisms on sleep and circadian disorders. (C) 2008 Elsevier B.V. All rights reserved.
Palavra-chave circadian rhythms
sleep disorders
casein kinase I epsilon
delayed sleep-phase syndrome
polymorphisms
Idioma Inglês
Financiador AFIP
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
CEPID
Número do financiamento FAPESP: 06/58104-2
CEPID: 98/143003-3
Data de publicação 2008-11-03
Publicado em Behavioural Brain Research. Amsterdam: Elsevier B.V., v. 193, n. 1, p. 156-157, 2008.
ISSN 0166-4328 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 156-157
Fonte http://dx.doi.org/10.1016/j.bbr.2008.05.005
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000258738400021
Endereço permanente http://repositorio.unifesp.br/handle/11600/31031

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