Applications of Europium Tetracycline Complex: A Review

Applications of Europium Tetracycline Complex: A Review

Autor Courrol, Lilia Coronato Autor UNIFESP Google Scholar
Samad, Ricardo E. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
IPEN CNEN SP
Resumo Europium solutions present low absorption coefficients and, due to the energy transfer between europium ions and the OH vibration of coordinated water molecules, there is a significant non-radiative relaxation and no emission is observed. However, when europium complexes with tetracycline (EuTc), it exhibits and intense and narrow emission band centered on 615 nm, characteristic of the (5)D(0) -> (5)F(2) transition within the lanthanide ion. the tetracycline molecule acts as an antenna or sensitizer, absorbing the excitation light and transferring the energy to the lanthanide ion.A major increase in the luminescence of the EuTc complex was observed in the presence of hydrogen peroxide and also urea hydrogen peroxide. the possibility of quantifying the hydrogen peroxide using luminescence measurements is also promising for the indirect quantification of glucose and cholesterol since enzymatic reactions generate hydrogen peroxide. This principle can be applied to determine, indirectly, concentrations of lactose and galactose, alcohol, catalase, etc.There are also other possibilities of EuTc applications: assay for phosphate, sensing and imaging of malate in aqueous solution, spectrofluorimetric determination of lecithin, heparin, human serum albumin, citrate and other intermediates in the citric acid cycle, low density lipoproteins (LDL), the determination of the activity of phosphorylation, immunoassays, etc.The purpose of this review is to describe and discuss the latest advances in analytical methodologies based in the luminescence properties of EuTc probes.
Palavra-chave Europium tetracycline
Lanthanides
Luminescent biosensors
Hydrogen peroxide
Urea hydrogen peroxide
glucose
DNA
LDL
Cholesterol
Idioma Inglês
Data de publicação 2008-11-01
Publicado em Current Pharmaceutical Analysis. Sharjah: Bentham Science Publ Ltd, v. 4, n. 4, p. 238-248, 2008.
ISSN 1573-4129 (Sherpa/Romeo, fator de impacto)
Publicador Bentham Science Publ Ltd
Extensão 238-248
Fonte http://dx.doi.org/10.2174/157341208786306216
Direito de acesso Acesso restrito
Tipo Resenha
Web of Science WOS:000261893400005
Endereço permanente http://repositorio.unifesp.br/handle/11600/31028

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