A panic attack-like unusual stress reaction

A panic attack-like unusual stress reaction

Autor Schenberg, Luiz Carlos Google Scholar
Reis, Adelina Martha dos Google Scholar
Ferreira Povoa, Raner Miguel Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Silva, Sara Regina Google Scholar
Instituição Univ Fed Espirito Santo
Universidade Federal de Minas Gerais (UFMG)
Universidade Federal de São Paulo (UNIFESP)
Resumo Ever since the seminal studies of Hans Selye, activation of hypothalamus-pituitary-adrenal (HPA) axis is emblematic of stress. Consequently, the lack of HPA axis responses following the undisputable psychological stress of a panic attack stands out as one of the most intriguing findings of contemporary psychiatry. On the other hand, the defensive behaviors and aversive emotions produced by stimulation of the dorsal periaqueductal gray matter (DPAG) have been proposed as a model of panic attacks. Therefore, we examined whether the plasma levels of 'stress hormones' corticotropin and prolactin show any change following the DPAG-evoked freezing and flight behaviors of the rat. Rats bearing an electrode into the DPAG and an intra-atrial catheter were stimulated at 9:00 a.m., 18-24 h after the catheter implantation. Blood samples were withdrawn just before 1-min stimulation of DPAG, immediately after (5 or 15 min) and throughout 3 to 27 h following stimulation. in another experiment, samples were withdrawn either before or following a prolonged stimulation (5 min) of the DPAG with flight threshold intensity. Hormones were measured by either chemiluminescent or double-antibody immunoassays. Hormone plasma levels following freezing and flight behaviors were compared to those of resting or restraint-stressed rats. Data show that stress hormones remain unaltered following the DPAG-evoked defensive behaviors. Not even the 5-min stimulation of DPAG with the flight threshold intensity changed corticotropin plasma levels significantly. As far as we known, this is the first demonstration of the lack of stress hormone responses following the intense emotional arousal and physical exertion of a fear-like behavior in rats. Data add new evidence of DPAG involvement in spontaneous panic attacks. (c) 2008 Elsevier Inc. All rights reserved.
Assunto Periaqueductal gray matter
Idioma Inglês
Financiador AFIP-UNIFESP
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Número do financiamento CNPq: 474371/2003-4
Data 2008-11-01
Publicado em Hormones and Behavior. San Diego: Academic Press Inc Elsevier Science, v. 54, n. 5, p. 584-591, 2008.
ISSN 0018-506X (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 584-591
Fonte http://dx.doi.org/10.1016/j.yhbeh.2008.02.019
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000261024300003
URI http://repositorio.unifesp.br/handle/11600/31016

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