Effect of hormonal replacement therapy in the hippocampus of ovariectomized epileptic female rats using the pilocarpine experimental model

Effect of hormonal replacement therapy in the hippocampus of ovariectomized epileptic female rats using the pilocarpine experimental model

Autor Valente, S. G. Autor UNIFESP Google Scholar
Marques, R. H. Google Scholar
Baracat, E. C. Google Scholar
Cavalheiro, E. A. Google Scholar
Naffah-Mazzacoratti, M. G. Google Scholar
Amado, D. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Amado and Cavalheiro [Amado, D., Cavatheiro, E.A., 1998. Hormonal and gestational parameters in female rats submitted to the pilocarpine model of epilepsy. Epilepsy Res. 32, 266-274], studying the establishment of the pilocarpine epilepsy model in female rats observed that the estrous cycle was dramatically altered during the three periods of this experimental model. This work was delineated to study the function of sexual hormones in the development of the epilepsy model induced by pilocarpine in ovariectomized rats. Experimental groups were: (a) control animals during estrus phase of the estrous cycle (E) and ovariectomized female rats (OVX) treated with saline instead of pilocarpine in the same volume, (b) experimental animals, that developed status epilepticus (SE) and were studied during the chronic phase of this model: intact chronic rats (CHRON) and ovariectomized chronic rats (CVX+CHRON) and (c) ovariectomized chronic rats, that were submitted to hormonal replacement therapy treated with: medroxyprogesterone (OVX + CHRON + MPA); 17 beta-estradiol (OVX + CHRON + E2), or both (OVX + CHRON + E2 + MPA). All ovariectomized animals showed genital atrophy 4 days after the surgical procedure. Moreover, all animals that developed SE and survived showed spontaneous recurrent seizures during the chronic phase. Concerning to seizure frequency, animals receiving medroxyprogesterone associated with 17 beta-estradiol showed decreased seizures' number. However, animals that received only medroxyprogesterone therapy also showed reduction in the number of seizures. in addition, hormonal treatment was also able to stabilize the mossy fibers sprouting process, showing the importance of these hormones in the development of the epilepsy in female rats. (C) 2008 Elsevier B.V. All rights reserved.
Palavra-chave Epilepsy
Ovariectomy
Hippocampus
Pilocarpine and Hormonal replacement therapy
Idioma Inglês
Financiador Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
PRONEX
FADA
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Data de publicação 2008-11-01
Publicado em Epilepsy Research. Amsterdam: Elsevier B.V., v. 82, n. 1, p. 46-56, 2008.
ISSN 0920-1211 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 46-56
Fonte http://dx.doi.org/10.1016/j.eplepsyres.2008.07.003
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000261634000007
Endereço permanente http://repositorio.unifesp.br/handle/11600/31007

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