Impact of a hospital-wide antimicrobial formulary intervention on the incidence of multidrug-resistant gram-negative bacteria

Impact of a hospital-wide antimicrobial formulary intervention on the incidence of multidrug-resistant gram-negative bacteria

Autor Furtado, Guilherme H. C. Autor UNIFESP Google Scholar
Perdiz, Luciana B. Autor UNIFESP Google Scholar
Santana, Iolanda Lopes Autor UNIFESP Google Scholar
Camargo, Marcia M. S. C. R. Autor UNIFESP Google Scholar
Parreira, Fernanda C. Autor UNIFESP Google Scholar
Angelieri, Daniela B. Autor UNIFESP Google Scholar
Medeiros, Eduardo A. S. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo We examined the impact of an antimicrobial formulary change, based on reduction in third-generation cephalosporin use, on resistant gram-negative pathogens in a tertiary hospital. No significant changes were demonstrated in their incidence per 1000 patient-days. Otherwise, there was a significant decrease in rate of extended-spectrum P-lactamase (ESBL)-producing Klebsiella pneumoniae (63.1 % to 52,5 %, P =.04) and third-generation cephalosporin-resistant Enterobacter species (31.4 % to 25%, P =.04) between the 2 study periods. On the other hand, there was also a significant increase in rate of ampicillin-sulbactam-resistant Acinetobacter baumannii (8% to 47%, P =.01) after the implementation of the formulary intervention. (Am J Infect Control 2008:36:661-4.)
Idioma Inglês
Data de publicação 2008-11-01
Publicado em American Journal of Infection Control. New York: Mosby-Elsevier, v. 36, n. 9, p. 661-664, 2008.
ISSN 0196-6553 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 661-664
Fonte http://dx.doi.org/10.1016/j.ajic.2007.11.014
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000260963300008
Endereço permanente http://repositorio.unifesp.br/handle/11600/31000

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