Angiogenesis and growth factor modulation induced by altelnagin C, a snake venom disintegrin-like, cysteine-rich protein on a rat skin wound model

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dc.contributor.author Correia St Ana, Estela Maria
dc.contributor.author Cacao Paiva Gouvea, Cibele Marli
dc.contributor.author Nakaie, Clovis Ryuichi [UNIFESP]
dc.contributor.author Selistre-de-Araujo, Heloisa Sobreiro
dc.date.accessioned 2016-01-24T13:51:50Z
dc.date.available 2016-01-24T13:51:50Z
dc.date.issued 2008-11-01
dc.identifier http://dx.doi.org/10.1016/j.abb.2008.07.030
dc.identifier.citation Archives of Biochemistry and Biophysics. New York: Elsevier B.V., v. 479, n. 1, p. 20-27, 2008.
dc.identifier.issn 0003-9861
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/30998
dc.description.abstract In this work, we show that alternagin-C (ALT-C) and ALT-C PEP, a peptide derived from its sequence, were able to induce angiogenesis ill Wounded rat skin. A spherical Cutaneous excision was made in the back of each animal and treated with three different concentrations of ALT-C or ALT-C PEP. After that, the skin was removed and analyzed to verify the presence of new vessels and the expression of growth factors. ALT-C and ALT-C PEP induced the formation of new vessels and modulated the expression of growth factors, mainly VEGF and FGH. the expression of VEGF increased and it Could be detected Up to 7 days after injury. FGH also significantly increased, but at a lesser extent than VEGF. in conclusion, the present Study shows for the first time the stimulation of angiogenesis in an injured tissue by a disintegrin-like protein and that ALT-C may exert this effect by modulating the expression of growth factors.(c) 2008 Elsevier Inc. All rights reserved. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 20-27
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Archives of Biochemistry and Biophysics
dc.rights Acesso restrito
dc.subject Disintegrin en
dc.subject Snake venom en
dc.subject Growth factors en
dc.subject Alternagin-C en
dc.subject Alpha2betal integrin en
dc.subject Bothrops alternatus en
dc.subject Angiogenesis en
dc.subject Skin wound en
dc.subject Rat model en
dc.subject ALT-C PEP en
dc.subject Peptide en
dc.title Angiogenesis and growth factor modulation induced by altelnagin C, a snake venom disintegrin-like, cysteine-rich protein on a rat skin wound model en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Carlos (UFSCar)
dc.contributor.institution Univ Fed Alfenas
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Fed Sao Carlos, Dept Ciencias Fisiol, BR-13565905 Sao Carlos, SP, Brazil
dc.description.affiliation Univ Fed Alfenas, Dept Ciencias Biol, BR-37130000 Alfenas, MG, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Biofis, BR-04044020 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Biofis, BR-04044020 São Paulo, Brazil
dc.identifier.doi 10.1016/j.abb.2008.07.030
dc.description.source Web of Science
dc.identifier.wos WOS:000260593400003



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