Angiogenesis and growth factor modulation induced by altelnagin C, a snake venom disintegrin-like, cysteine-rich protein on a rat skin wound model

Angiogenesis and growth factor modulation induced by altelnagin C, a snake venom disintegrin-like, cysteine-rich protein on a rat skin wound model

Autor Correia St Ana, Estela Maria Google Scholar
Cacao Paiva Gouvea, Cibele Marli Google Scholar
Nakaie, Clovis Ryuichi Autor UNIFESP Google Scholar
Selistre-de-Araujo, Heloisa Sobreiro Google Scholar
Instituição Universidade Federal de São Carlos (UFSCar)
Univ Fed Alfenas
Universidade Federal de São Paulo (UNIFESP)
Resumo In this work, we show that alternagin-C (ALT-C) and ALT-C PEP, a peptide derived from its sequence, were able to induce angiogenesis ill Wounded rat skin. A spherical Cutaneous excision was made in the back of each animal and treated with three different concentrations of ALT-C or ALT-C PEP. After that, the skin was removed and analyzed to verify the presence of new vessels and the expression of growth factors. ALT-C and ALT-C PEP induced the formation of new vessels and modulated the expression of growth factors, mainly VEGF and FGH. the expression of VEGF increased and it Could be detected Up to 7 days after injury. FGH also significantly increased, but at a lesser extent than VEGF. in conclusion, the present Study shows for the first time the stimulation of angiogenesis in an injured tissue by a disintegrin-like protein and that ALT-C may exert this effect by modulating the expression of growth factors.(c) 2008 Elsevier Inc. All rights reserved.
Palavra-chave Disintegrin
Snake venom
Growth factors
Alternagin-C
Alpha2betal integrin
Bothrops alternatus
Angiogenesis
Skin wound
Rat model
ALT-C PEP
Peptide
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Data de publicação 2008-11-01
Publicado em Archives of Biochemistry and Biophysics. New York: Elsevier B.V., v. 479, n. 1, p. 20-27, 2008.
ISSN 0003-9861 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 20-27
Fonte http://dx.doi.org/10.1016/j.abb.2008.07.030
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000260593400003
Endereço permanente http://repositorio.unifesp.br/handle/11600/30998

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