Stromal and epithelial cells react differentially to c-kit in fibroepithelial tumors of the breast

Stromal and epithelial cells react differentially to c-kit in fibroepithelial tumors of the breast

Autor Logullo, Angela F. Autor UNIFESP Google Scholar
Nonogaki, Suely Google Scholar
Maciel, Maria Do Socorro Google Scholar
Mourao-Neto, Mario Google Scholar
Soares, Fernando Augusto Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Hosp Canc
Resumo The CD117 protein is a tyrosine-kinase receptor encoded by the c-kit gene that frequently bears activating mutations in gastrointestinal tumors. Conflicting findings regarding CD117 expression in other stromal tumors, including phyllodes tumors (PTs), have been reported in the literature. the purpose of this study was to evaluate c-kit expression in the stroma and epithelia of fibroepithelial breast tumors and its correlation with clinical pathological variables. Ninety-six fibroepithelial tumors of the breast, including 14 fibroadenomas (FAs), 12 juvenile FAs and 70 PTs, were classified according to stromal cellularity, atypia, epithelial hyperplasia, mitosis and borders into 45 benign (PTB), 17 borderline (PTBL) and 8 malignant (PTM) tumors. CD117 expression was identified in the stromal component in only two cases of PTBL. Overall, 38 cases (39.6%) showed positive CD117 in the epithelial component, including 20 FAs (10 regular, 10 juvenile) and 18 PTs (11 PTBs and 8 PTBLs). Other cases, including all PTMs, 6 FAs (4 regular, 2 juvenile), 34 PTBs and 10 PTBLs, showed no positivity in the epithelial component. Expression of c-kit did not correlate with diagnosis or malignancy (p>0.05). in conclusion, c-kit is expressed more often in the epithelial than in the stromal component in fibroepithelial tumors of the breast, and is associated with benign lesions.
Palavra-chave proto-oncogene protein c-kit
phyllodes tumor
fibroepithelial neoplasms
breast neoplasms
immunohistochemistry
Idioma Inglês
Data de publicação 2008-11-01
Publicado em Molecular Medicine Reports. Athens: Spandidos Publ Ltd, v. 1, n. 6, p. 857-861, 2008.
ISSN 1791-2997 (Sherpa/Romeo, fator de impacto)
Publicador Spandidos Publ Ltd
Extensão 857-861
Fonte http://dx.doi.org/10.3892/mmr_00000041
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000261058300015
Endereço permanente http://repositorio.unifesp.br/handle/11600/30986

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