From yeast killer toxins to antibiobodies and beyond

From yeast killer toxins to antibiobodies and beyond

Author Magliani, Walter Google Scholar
Conti, Stefania Google Scholar
Travassos, Luiz R. Autor UNIFESP Google Scholar
Polonelli, Luciano Google Scholar
Institution Univ Parma
Universidade Federal de São Paulo (UNIFESP)
Abstract Antibiobodies are paradigmatic of yeast killer toxin (KT)-like antibodies (KAbs) mimicking the antimicrobial activity of KTs in the frame of the yeast killer phenomenon. Polyclonal, monoclonal and recombinant anti-idiotypic antibiobodies (anti-idiotypic KAbs), internal images of a wide-spectrum KT produced by the yeast Pichia anomala (PaKT), have been produced by immunization with the idiotype of a PaKT-neutralizing monoclonal antibody. Anti-idiotypic KAbs showed microbicidal activity against eukaryotic and prokaryotic pathogenic agents through the interaction with specific KT receptors (KTRs), putatively constituted by beta-glucans. Natural KAbs have been found in animals and humans experimentally or naturally infected by KTR-bearing microorganisms. Recombinant KAb-derived synthetic killer peptides showed further antiviral and immunomodulatory activities. the perspectives of KAbs and killer peptides as potential sources of novel therapeutic agents, and of KTRs and idiotypes as vaccines against infectious diseases are discussed.
Keywords antibiobodies
killer peptides
killer toxins
microbicidal antibodies
microbicidal peptides
Language English
Sponsor Istituto Superiore di Sanita
Date 2008-11-01
Published in Fems Microbiology Letters. Malden: Wiley-Blackwell, v. 288, n. 1, p. 1-8, 2008.
ISSN 0378-1097 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 1-8
Origin http://dx.doi.org/10.1111/j.1574-6968.2008.01340.x
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000259524600001
URI http://repositorio.unifesp.br/handle/11600/30984

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