Mechanistic hypotheses for nonsynaptic epileptiform activity induction and its transition from the interictal to ictal state-Computational simulation

Mechanistic hypotheses for nonsynaptic epileptiform activity induction and its transition from the interictal to ictal state-Computational simulation

Autor Almeida, Antonio-Carlos G. de Google Scholar
Rodrigues, Antonio M. Google Scholar
Scorza, Fulvio A. Autor UNIFESP Google Scholar
Cavalheiro, Esper Abrão Autor UNIFESP Google Scholar
Teixeira, Hewerson Z. Google Scholar
Duarte, Mario A. Google Scholar
Silveira, Gilcelio A. Google Scholar
Arruda, Emerson Z. Google Scholar
Instituição Univ Fed Sao Joao del Rei
Universidade Federal de São Paulo (UNIFESP)
Resumo The aim of this work is to study, by means of computational simulations, the induction and sustaining of nonsynaptic epileptiform activity.The computational model consists of a network of cellular bodies of neurons and glial cells connected to a three-dimensional (3D) network of juxtaposed extracellular compartments. the extracellular electrodiffusion calculation was used to simulate the extracellular potential. Each cellular body was represented in terms of the transmembrane ionic transports (Na(+)/K(+) pumps, ionic channels, and cotransport mechanisms), the intercellular electrodiffusion through gap-junctions, and the neuronal interaction by electric field and the variation of cellular volume.The computational model allows simulating the nonsynaptic epileptiform activity and the extracellular potential captured the main feature of the experimental measurements. the simulations of the concomitant ionic fluxes and concentrations can be used to propose the basic mechanisms involved in the induction and sustaining of the activities.The simulations suggest: the bursting induction is mediated by the Cl(-) Nernst potential overcoming the transmembrane potential in response to the extracellular [K(+)] increase. the burst onset is characterized by a critical point defined by the instant when the Na(+) influx through its permeable ionic channels overcomes the Na(+)/K(+) pump electrogenic current. the burst finalization is defined by another critical point, when the electrogenic current of the Na(+)/K(+) pump overcomes its influx through the channels.
Palavra-chave Epilepsy
Nonsynaptic epilepsy
Mathematical model
Interictal state
Ictal state
Transition
Idioma Inglês
Financiador Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Data de publicação 2008-11-01
Publicado em Epilepsia. Malden: Wiley-Blackwell, v. 49, n. 11, p. 1908-1924, 2008.
ISSN 0013-9580 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 1908-1924
Fonte http://dx.doi.org/10.1111/j.1528-1167.2008.01686.x
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000260744200010
Endereço permanente http://repositorio.unifesp.br/handle/11600/30983

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