MYC and gastric adenocarcinoma carcinogenesis

MYC and gastric adenocarcinoma carcinogenesis

Author Calcagno, Danielle Queiroz Google Scholar
Leal, Mariana Ferreira Autor UNIFESP Google Scholar
Assumpcao, Paulo Pimentel Google Scholar
Smith, Marilia de Arruda Cardoso Autor UNIFESP Google Scholar
Burbano, Rommel Rodriguez Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Fed Univ Para
Abstract MYC is an oncogene involved in cell cycle regulation, cell growth arrest, cell adhesion, metabolism, ribosome biogenesis, protein synthesis, and mitochondrial function. It has been described as a key element of several carcinogenesis processes in humans. Many studies have shown an association between MYC deregulation and gastric cancer. MYC deregulation is also seen in gastric preneoplastic lesions and thus it may have a role in early gastric carcinogenesis. Several studies have suggested that amplification is the main mechanism of MYC deregulation in gastric cancer. in the present review, we focus on the deregulation of the MYC oncogene in gastric adenocarcinorna carcinogenesis, including its association with Helicobacterpylori (Hpylorl) and clinical applications. (c) 2008 the WIG Press. All rights reserved.
Keywords MYC
Gastric adenocarcinoma
Gastric preneoplastic lesions
Gastric carcinogenesis
Helicobacter pylori
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2008-10-21
Published in World Journal of Gastroenterology. Beijing: Baishideng Publ Grp Co Ltd, v. 14, n. 39, p. 5962-5968, 2008.
ISSN 1007-9327 (Sherpa/Romeo, impact factor)
Publisher Baishideng Publ Grp Co Ltd
Extent 5962-5968
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000260384100002

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