Efeito neuroprotetor da melatonina e N-acetilserotonina na epileptogênese e no controle de crises em animais submetidos ao modelo da pilocarpina

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dc.contributor.author Lima, Eliângela de [UNIFESP]
dc.contributor.author Cabral, Francisco Romero [UNIFESP]
dc.contributor.author Cavalheiro, Esper Abrão [UNIFESP]
dc.contributor.author Naffah-Mazzacoratti, Maria da Graca [UNIFESP]
dc.contributor.author Amado, Débora [UNIFESP]
dc.date.accessioned 2015-06-14T13:32:08Z
dc.date.available 2015-06-14T13:32:08Z
dc.date.issued 2006-06-01
dc.identifier http://dx.doi.org/10.1590/S1676-26492006000300006
dc.identifier.citation Journal of Epilepsy and Clinical Neurophysiology. Liga Brasileira de Epilepsia (LBE), v. 12, n. 2, p. 75-78, 2006.
dc.identifier.issn 1676-2649
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/3096
dc.description.abstract PURPOSE: The aim of this research was to study the effects of treatment with melatonin and N-acetilserotonin in the development of pilocarpina model of epilepsy in adult male rats. METHODS: Part I - The animals were divided in 4 groups: SALINE - animals that received only saline; SE - animals submitted to status epilepticus (SE); NAS + SE - animals that received pre-treatment with N-acetylserotonin and were submitted to SE and MEL + SE - animals that received pre-treatment with melatonin and were submitted to SE. Part II - The animals were divided in 6 groups: SALINE - animals that received only saline; SE - animals submitted to status epilepticus (SE); PX + SE - animals submitted to pinealectomy and to SE 7 days later; SH + SE - animals submitted to sham-surgery and to SE 7 days later; SE + NAS - animals submitted to SE and treated with N-acetylserotonin (2,5 mg/kg), 30 min, 1 h, 2 h, 4 h, 6 h, 12 h, 24 h, 36 h and 48 h after the SE and SE + MEL - animals submitted to SE and treated with melatonin (2,5 mg/kg), 30 min, 1 h, 2 h, 4 h, 6 h, 12 h, 24 h, 36 h and 48 h after the SE. Following the treatment the animals were continuously video-recorded for 60 days. The behavioral parameters were observed: latency for the SE in minutes, latency for the first spontaneous seizures (ie, duration of the silent period), number of spontaneous seizures during the chronic period and mortality. Five animals per group were perfused for neo-Timm assay. RESULTS: Part I - The animals treated with melatonin and N-acetylserotonin presented an increased of latency for the status epilepticus and decreased number of spontaneous seizures during the chronic period when compared to SE group. The mortality was reduced 100% in animals treated with melatonin and theses animals presented a minor mossy fibers sprouting. Part II - The latency for the first spontaneous seizures and mortality were similar in all groups. The animals treated with melatonin presented a decreased number of spontaneous seizures during the chronic period when compared to PX + SE group and a minor mossy fibers sprouting when compared to SE, SH + SE and PX + SE groups. CONCLUSION: Our data show that the melatonin and N-acetylserotonin have an important neuroprotector effect in the epileptogenesis and in the control of seizures during the chronic period of the pilocarpina model of epilepsy induced by pilocarpina. en
dc.format.extent 75-78
dc.language.iso por
dc.publisher Liga Brasileira de Epilepsia (LBE)
dc.relation.ispartof Journal of Epilepsy and Clinical Neurophysiology
dc.rights Acesso aberto
dc.subject melatonin en
dc.subject N-acetylserotonin en
dc.subject temporal lobe epilepsy en
dc.subject hippocampal en
dc.subject experimental model en
dc.subject melatonina pt
dc.subject N-acetilserotonina pt
dc.subject epilepsia do lobo temporal pt
dc.subject hipocampo pt
dc.subject modelo experimental pt
dc.title Efeito neuroprotetor da melatonina e N-acetilserotonina na epileptogênese e no controle de crises em animais submetidos ao modelo da pilocarpina pt
dc.title.alternative Neuroprotector effect of melatonin and N-acetilserotonin in the epileptogenesis and in the control of seizures in animals submitted to the pilocarpine model en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina
dc.description.affiliationUnifesp UNIFESP, EPM
dc.identifier.file S1676-26492006000300006.pdf
dc.identifier.scielo S1676-26492006000300006
dc.identifier.doi 10.1590/S1676-26492006000300006
dc.description.source SciELO



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