Photodynamic potentiality of hypocrellin B and its lanthanide complexes

Photodynamic potentiality of hypocrellin B and its lanthanide complexes

Autor Toffoli, D. J. Google Scholar
Gomes, L. Google Scholar
Vieira, N. D. Google Scholar
Courrol, L. C. Autor UNIFESP Google Scholar
Instituição IPEN CNEN
Universidade Federal de São Paulo (UNIFESP)
Resumo The search for new photosensitizers with strong absorption bands, fast elimination from the body and high singlet oxygen generation quantum yield has been the subject of intensive research over the past two decades. Perylenequinonoid pigments, such as hypocrellins and hypericin, stand out among other photosensitizers due to their remarkable properties, which fulfil these requirements. Besides, it was shown that hypocrellin B complexes with metal ions possess even more notable optical and photodynamic properties. in this work, a study of the photosensitizer hypocrellin B and its complexes formed with the lanthanide ions europium, lanthanum and terbium, in ethanol and dimethyl sulfoxide solutions, was carried out by spectroscopic methods, with the purpose of verifying its potentiality for use in photodynamic therapy. the photobleaching of this molecule was also investigated, and our results show that, under experimental conditions, there is a significant decrease in HB emission intensity after about 30 min of exposure to white light. Moreover, lanthanide ions are able to modify hypocrellin B energy levels, as well as its radioactive decay probabilities. Infrared emission revealed the capacity of these complexes for generating singlet oxygen. Hypocrellin B complex with lanthanum in ethanol showed the best results among the studied complexes regarding optical characteristics of ideal photosensitizers, since it induced the larger redshift of about 30 nm, as well as enhanced HB singlet oxygen generation quantum yield of about 32%.
Assunto hypocrellin B
photodynamic therapy
singlet oxygen
Idioma Inglês
Financiador Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Data 2008-10-01
Publicado em Journal of Optics A-pure and Applied Optics. Bristol: Iop Publishing Ltd, v. 10, n. 10, 8 p., 2008.
ISSN 1464-4258 (Sherpa/Romeo, fator de impacto)
Editor Iop Publishing Ltd
Extensão 8
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000259700100027

Mostrar registro completo

Arquivos deste item

Arquivos Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item aparece na(s) seguinte(s) coleção(s)