Impact of Prolonged Physical Training on the Pituitary Glucocorticoid Sensitivity Determined by Very Low Dose Intravenous Dexamethasone Suppression Test

Impact of Prolonged Physical Training on the Pituitary Glucocorticoid Sensitivity Determined by Very Low Dose Intravenous Dexamethasone Suppression Test

Autor Silva, T. S. Google Scholar
Longui, C. A. Google Scholar
Faria, C. D. C. Google Scholar
Rocha, M. N. Google Scholar
Melo, M. R. Google Scholar
Faria, T. G. Google Scholar
Souza e Almeida, J. A. de Google Scholar
Hayashi, L. F. Autor UNIFESP Google Scholar
Kater, C. E. Autor UNIFESP Google Scholar
Instituição Santa Casa São Paulo Fac Med Sci
Brazilian AF Acad Pirassununga
Universidade Federal de São Paulo (UNIFESP)
Resumo The activity of the hypothalamic-pituitary-adrenal axis is usually modulated by several stress factors, including exercise. Different responses are induced by physical training according to duration and intensity of exercise. During prolonged training, cortisol remains normal or decreased as a consequence of altered cortisol secretion, metabolism and excretion, and possibly by changes in glucocorticoid sensitivity. the aim of this study was to evaluate the impact of prolonged physical training on the glucocorticoid sensitivity. Eighteen cadets of the Air Force Academy, mean (SD) age: 18.7 (1.0) years, underwent an intensive 6-week preparatory training-period considered adequate by inducing significant changes on body composition measured by bioelectrical impedance. Measurement of individual's pituitary glucocorticoid sensitivity was done by an intravenous very low dose dexamethasone suppression test (20 mu g/m(2)) that was performed before and after the training period. Cortisol levels were obtained at basal condition and 120 minutes after the dexamethasone infusion. Basal cortisol showed a significant decrease after prolonged training. the percent cortisol suppression after dexamethasone tended to be lower after the training period. Overall, our data suggest that prolonged physical training is able to reduce glucocorticoid sensitivity, which can have a beneficial impact in chronic stress conditions.
Palavra-chave HPA axis
glucocorticoid action
bioelectrical impedance
exercise
negative feedback
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Número do financiamento FAPESP: 04/03208-2
Data de publicação 2008-10-01
Publicado em Hormone and Metabolic Research. Stuttgart: Georg Thieme Verlag Kg, v. 40, n. 10, p. 718-721, 2008.
ISSN 0018-5043 (Sherpa/Romeo, fator de impacto)
Publicador Georg Thieme Verlag Kg
Extensão 718-721
Fonte http://dx.doi.org/10.1055/s-2008-1078727
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000260221800011
Endereço permanente http://repositorio.unifesp.br/handle/11600/30954

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