Use of respiratory medication in five Latin American cities: the PLATINO study

Use of respiratory medication in five Latin American cities: the PLATINO study

Author Oca, Maria Montes de Google Scholar
Talamo, Carlos Google Scholar
Perez-Padilla, Rogelio Google Scholar
Lopez, Maria Victorina Google Scholar
Muino, Adriana Google Scholar
Jardim, Jose Roberto B. Autor UNIFESP Google Scholar
Valdivia, Gonzalo Google Scholar
Pertuze, Julio Google Scholar
Moreno, Dolores Google Scholar
Halbert, Ronald J. Google Scholar
Menezes, Ana Maria B. Google Scholar
PLATINO Team Google Scholar
Institution Cent Univ Venezuela
Inst Resp Dis
Univ Republica
Universidade Federal de São Paulo (UNIFESP)
Pontificia Univ Catolica Chile
Univ Calif Los Angeles
Univ Fed Pelotas
Abstract Background: There is scanty information regarding respiratory medication prescription pattern in Latin America. We examined the use of bronchodilators and corticosteroids in a population-based study conducted in five Latin American cities.Methods: Medication use was derived from questions regarding the use of medication to help breathing within the previous 12 months, type of medicine, and frequency of use. To minimize the possibility of overdiagnosis, we used postbronchodilator FEV(1)/FVC < 0.70 plus FEV(1)< 80% as the definition of obstruction.Results: Interviews were completed in 5571 subjects from 6711 eligible individuals, and spirometry was performed in 5314 subjects. There were 360 (6.5%) treated subjects and 5211 not treated. Treated subjects were more likely to be older, women, unemployed, have higher tobacco consumption, higher body mass index, higher FEV, reversibility and airway obstruction. They were also more likely to report prior spirometry, prior diagnosis of COPD, asthma or tuberculosis, and more respiratory symptoms. Over half of treated subjects had neither obstruction nor FEV, reversibility, and approximately 30% reported no prior diagnosis of asthma or COPD. Prior respiratory diagnoses and wheezing were more strongly associated with treatment than objective measures of airway obstruction.Conclusions: the use of bronchodilators and/or corticosteroids is common in the general population aged 40 years or older, with over one-half of treated subjects using them without being obstructed. (c) 2008 Elsevier B.V. All rights reserved.
Keywords Bronchodilators
Chronic obstructive pulmonary disease
Language English
Sponsor Asociacion Latinoamericana de Torax (ALAT)
Boehringer Ingelheim GmbH
Date 2008-10-01
Published in Pulmonary Pharmacology & Therapeutics. London: Academic Press Ltd Elsevier B.V., v. 21, n. 5, p. 788-793, 2008.
ISSN 1094-5539 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 788-793
Access rights Closed access
Type Article
Web of Science ID WOS:000262944200012

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