Neurodevelopmental basis of bipolar disorder: A critical appraisal

Neurodevelopmental basis of bipolar disorder: A critical appraisal

Author Sanches, Marsal Autor UNIFESP Google Scholar
Keshavan, Matcheri S. Google Scholar
Brambilla, Paolo Google Scholar
Soares, Jair C. Google Scholar
Institution Univ N Carolina
Univ Texas Hlth Sci Ctr San Antonio
Audie L Murphy Div
Universidade Federal de São Paulo (UNIFESP)
Wayne State Univ
Univ Udine
Abstract Neurodevelopmental factors have been implicated in the pathophysiology of mental disorders. However, the evidence regarding their role in bipolar disorder is controversial. We reviewed the pertinent literature searching for evidence regarding a neurodevelopmental origin of bipolar disorder. Findings from clinical, epidemiological, neuroimaging, and post-mortem studies are discussed, as well as the implications of the available data for a better understanding of the mechanisms involved in the genesis of bipolar disorder. While some evidence exists for developmental risk factors in bipolar disorder, further research is needed to determine the precise extent of their contribution to pathogenesis. the timing and course of such developmentally mediated neurobiological alterations also need to be determined. of particular importance for further study is the possibility that bipolar disorder may be mediated by an abnormal maturation of brain structures involved in affect regulation. (c) 2008 Published by Elsevier Inc.
Keywords bipolar disorder
magnetic resonance imaging
mood disorders
Language English
Krus Endowed Chair in Psychiatry (UTHSCSA)
Veterans Administration (VA Merit Review)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number UTHSCSA GCRC: M01-RR-01346
: MH 01736
: MH 068662
: MH 068766
: MH 69774
: MH 64023
: RR020571
Date 2008-10-01
Published in Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 32, n. 7, p. 1617-1627, 2008.
ISSN 0278-5846 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 1617-1627
Access rights Closed access
Type Review
Web of Science ID WOS:000259843500001

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