Antinociceptive effect of the C-terminus of murine S100A9 protein on experimental neuropathic pain

Antinociceptive effect of the C-terminus of murine S100A9 protein on experimental neuropathic pain

Autor Paccola, Carina Cicconi Google Scholar
Gutierrez, Vanessa Pacciari Google Scholar
Longo, Ingrid Google Scholar
Juliano, Luiz Autor UNIFESP Google Scholar
Juliano, Maria Aparecida Autor UNIFESP Google Scholar
Giorgi, Renata Google Scholar
Instituição Butantan Inst
Universidade Federal de São Paulo (UNIFESP)
Resumo The synthetic peptide identical to the C-terminus of murine S100A9 protein (mS100A9p) has antinociceptive effect on different acute inflammatory pain models. in this study, the effect of mS100A9p was investigated on neuropathic pain induced by chronic constriction injury (CCI) of the sciatic nerve in rats. Hyperalgesia, allodynia, and spontaneous pain were assessed to evaluate nociception. These three signs were detected as early as 2 days after sciatic nerve constriction and lasted for over 14 days after CCI. Rats were treated with different doses of mS100A9p by intraplantar, oral, or intrathecal routes on day 14 after CCI, and nociception was evaluated 1 h later. These three routes of administration blocked hyperalgesia, allodynia and spontaneous pain. the duration of the effect of mS100A9p depends on the route used and phenomenon analyzed. Moreover, intraplantar injection of mS100A9p in the contralateral paw inhibited the hyperalgesia on day 14 days after CCI the results obtained herein demonstrate the antinociceptive effect of the C-terminus of murine S100A9 protein on experimental neuropathic pain, suggesting a potential therapeutic use for it in persistent pain syndromes, assuming that tolerance does not develop to mS100A9p. (C) 2008 Elsevier Inc. All rights reserved.
Palavra-chave Neuropathic pain
S100A9
Antinociception
Sciatic nerve
Chronic constriction injury
Idioma Inglês
Financiador Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Fundacao Butantan
Data de publicação 2008-10-01
Publicado em Peptides. New York: Elsevier B.V., v. 29, n. 10, p. 1806-1814, 2008.
ISSN 0196-9781 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 1806-1814
Fonte http://dx.doi.org/10.1016/j.peptides.2008.05.023
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000260284100022
Endereço permanente http://repositorio.unifesp.br/handle/11600/30946

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