Additive effect of P10 immunization and chemotherapy in anergic mice challenged intratracheally with virulent yeasts of Paracoccidioides brasiliensis

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dc.contributor.author Marques, Alexandre F.
dc.contributor.author Silva, Marcelo B. da
dc.contributor.author Juliano, Maria A. P. [UNIFESP]
dc.contributor.author Munhoz, Julian E.
dc.contributor.author Travassos, Luiz R. [UNIFESP]
dc.contributor.author Taborda, Carlos Pelleschi [UNIFESP]
dc.date.accessioned 2016-01-24T13:51:44Z
dc.date.available 2016-01-24T13:51:44Z
dc.date.issued 2008-10-01
dc.identifier http://dx.doi.org/10.1016/j.micinf.2008.07.027
dc.identifier.citation Microbes and Infection. Amsterdam: Elsevier B.V., v. 10, n. 12-13, p. 1251-1258, 2008.
dc.identifier.issn 1286-4579
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/30943
dc.description.abstract Paracoccidioidomycosis is a systemic granulomatous disease manifested in the acute/subacute or chronic forms. the anergic cases of the acute/subacute form are most severe, leading to death threatening conditions. Drug treatment is required to control the disease but the response in anergic patients is generally poor. A 15-mer peptide from the major diagnostic antigen gp43, named P10, induces a T-CD4(+) helper-1 immune response in mice of different haplotypes and protects against intratracheal challenge with virulent P. brasiliensis. Presently, P10 immunization and chemotherapy were associated in an attempt to improve antifungal treatment in Balb/c mice made anergic by adding dexamethasone to the drinking water. the combined drug/peptide treatment significantly reduced the lung CFUs in infected anergic mice, largely preserved lung alveolar structure and prevented fungal dissemination to liver and spleen. Results recommend that a P10-based vaccine should be associated to chemotherapy for improved treatment of paracoccidioidomycosis aiming especially at anergic cases. (C) 2008 Elsevier Masson SAS. All rights reserved. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 1251-1258
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Microbes and Infection
dc.rights Acesso restrito
dc.subject P. brasiliensis en
dc.subject Anergy en
dc.subject Dexamethasone en
dc.subject Chemotherapy en
dc.subject Immunization en
dc.subject P10 en
dc.subject gp43 en
dc.title Additive effect of P10 immunization and chemotherapy in anergic mice challenged intratracheally with virulent yeasts of Paracoccidioides brasiliensis en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ São Paulo, Dept Microbiol, Inst Biomed Sci, BR-05508900 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Biophys, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Biophys, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 07/07588-2
dc.description.sponsorshipID FAPESP: 06/50634-2
dc.description.sponsorshipID CNPq: 470636/2007-6
dc.identifier.doi 10.1016/j.micinf.2008.07.027
dc.description.source Web of Science
dc.identifier.wos WOS:000261368400004



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