Additive effect of P10 immunization and chemotherapy in anergic mice challenged intratracheally with virulent yeasts of Paracoccidioides brasiliensis

Additive effect of P10 immunization and chemotherapy in anergic mice challenged intratracheally with virulent yeasts of Paracoccidioides brasiliensis

Autor Marques, Alexandre F. Google Scholar
Silva, Marcelo B. da Google Scholar
Juliano, Maria A. P. Autor UNIFESP Google Scholar
Munhoz, Julian E. Google Scholar
Travassos, Luiz R. Autor UNIFESP Google Scholar
Taborda, Carlos P. Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo Paracoccidioidomycosis is a systemic granulomatous disease manifested in the acute/subacute or chronic forms. the anergic cases of the acute/subacute form are most severe, leading to death threatening conditions. Drug treatment is required to control the disease but the response in anergic patients is generally poor. A 15-mer peptide from the major diagnostic antigen gp43, named P10, induces a T-CD4(+) helper-1 immune response in mice of different haplotypes and protects against intratracheal challenge with virulent P. brasiliensis. Presently, P10 immunization and chemotherapy were associated in an attempt to improve antifungal treatment in Balb/c mice made anergic by adding dexamethasone to the drinking water. the combined drug/peptide treatment significantly reduced the lung CFUs in infected anergic mice, largely preserved lung alveolar structure and prevented fungal dissemination to liver and spleen. Results recommend that a P10-based vaccine should be associated to chemotherapy for improved treatment of paracoccidioidomycosis aiming especially at anergic cases. (C) 2008 Elsevier Masson SAS. All rights reserved.
Palavra-chave P. brasiliensis
Anergy
Dexamethasone
Chemotherapy
Immunization
P10
gp43
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Número do financiamento FAPESP: 07/07588-2
FAPESP: 06/50634-2
CNPq: 470636/2007-6
Data de publicação 2008-10-01
Publicado em Microbes and Infection. Amsterdam: Elsevier B.V., v. 10, n. 12-13, p. 1251-1258, 2008.
ISSN 1286-4579 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 1251-1258
Fonte http://dx.doi.org/10.1016/j.micinf.2008.07.027
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000261368400004
Endereço permanente http://repositorio.unifesp.br/handle/11600/30943

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