Genomic instability in blood cells is able to predict the oral cancer risk: an experimental study in rats

Genomic instability in blood cells is able to predict the oral cancer risk: an experimental study in rats

Autor Ribeiro, Daniel A. Autor UNIFESP Google Scholar
Grilli, Daniela G. Autor UNIFESP Google Scholar
Salvadori, Daisy M. F. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo This study was undertaken to investigate the genomic instability on blood cells during 4-nitroquinoline 1-oxide (4NQO)-induced rat tongue carcinogenesis by means of single cell gel (comet) and micronucleus assays. Male Wistar rats were distributed into three groups of 10 animals each and treated with 50 ppm 4NQO solution through their drinking water for 4, 12, and 20 weeks. Ten animals were used as negative control. Although no histopathological abnormalities were induced in the epithelium after 4 weeks of carcinogen exposure, genetic damage was found in blood cells as depicted by the mean tail moment and an increase of micronucleated polychromatic erythrocytes. After 12 and 20 weeks treatment, the same picture occurred, being the strong effect observed in the micronucleus induction. These periods correspond to pre-neoplastic lesions and well-differentiated squamous cell carcinomas, respectively. Taken together, our results support the idea that genomic instability on blood cells appears to be associated with the risk and progression of oral cancer, being a reliable tool for detecting early systemic conditions of malignancy.
Palavra-chave genomic instability
rat tongue mucosa
oral squamous cell carcinoma
4-Nitroquinoline 1-oxide
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Número do financiamento FAPESP: 07/01228-4
Data de publicação 2008-10-01
Publicado em Journal of Molecular Histology. Dordrecht: Springer, v. 39, n. 5, p. 481-486, 2008.
ISSN 1567-2379 (Sherpa/Romeo, fator de impacto)
Publicador Springer
Extensão 481-486
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000259672000002
Endereço permanente

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