Fermented soy product supplemented with isoflavones affects adipose tissue in a regional-specific manner and improves HDL-cholesterol in rats fed on a cholesterol-enriched diet

Mostrar registro simples

dc.contributor.author Jovenasso Manzoni, Marla S.
dc.contributor.author Rossi, Elizeu A.
dc.contributor.author Carlos, Iracilda Z.
dc.contributor.author Vendramini, Regina C.
dc.contributor.author Duarte, Ana C. G. O. [UNIFESP]
dc.contributor.author Tenorio, Neuli M. [UNIFESP]
dc.contributor.author Amorim, Danielle B. [UNIFESP]
dc.contributor.author Damaso, Ana R. [UNIFESP]
dc.date.accessioned 2016-01-24T13:51:44Z
dc.date.available 2016-01-24T13:51:44Z
dc.date.issued 2008-10-01
dc.identifier http://dx.doi.org/10.1007/s00217-008-0883-1
dc.identifier.citation European Food Research and Technology. New York: Springer, v. 227, n. 6, p. 1591-1597, 2008.
dc.identifier.issn 1438-2377
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/30936
dc.description.abstract It has been proposed that isoflavones and probiotics possess specific biological activities that enable them to affect lipid metabolism. the purpose of this study was to evaluate the effects of a soy product fermented with Enterococcus faecium and Lactobacillus jugurti and supplemented with isoflavones on the plasma lipid and glucose profiles, and on the retroperitoneal (RET) and epididymal (EPI) adipose tissue adipocyte areas in juvenile rats. Male Wistar rats were subjected to 6-week experimental diets: (1) cholesterol-enriched diet (rat chow) plus fermented soy product supplemented with isoflavones, (2) cholesterol-enriched diet plus unfermented placebo, (3) cholesterol-enriched diet plus placebo supplemented with isoflavones, (4) standard diet (rat chow), or (5) cholesterol-enriched diet. Soy products affected adipose tissue in a regional-specific manner and may be responsible for the observed increase in RET adipocyte area (mu(2)): (1) 12757.00 +/- 286.25; (2) 13269.00 +/- 326.87 or (3) 13050.00 +/- 226.85 versus (4) 8714.92 +/- 262.41 or (5) 8892.70 +/- 131.79 or decrease in EPI adipocyte area (mu(2)): (1) 7759.00 +/- 108.89 and (2) 7481.90 +/- 111.21 compared with the control group (4) 8346.60 +/- 158.89. the effect on epididymal adipose tissue was probably due to isoflavones. Probiotics significantly raised the plasma level of HDL cholesterol. Fermented soy product supplemented with isoflavones did not promote changes in the glucose and triglyceride plasma levels. This product may offer a new approach for improving or preventing lipid metabolism abnormalities by decreasing visceral adipocyte area, adjusting cholesterol-mediated loss of RET adipose tissue (lipoatrophy), and increasing the HDL cholesterol plasma level. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Cientificoe Tecnologico
dc.format.extent 1591-1597
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof European Food Research and Technology
dc.rights Acesso restrito
dc.subject fermented soy product en
dc.subject isoflavones en
dc.subject probiotic en
dc.subject adipose tissue en
dc.subject lipid levels en
dc.subject cholesterol-enriched diet en
dc.title Fermented soy product supplemented with isoflavones affects adipose tissue in a regional-specific manner and improves HDL-cholesterol in rats fed on a cholesterol-enriched diet en
dc.type Artigo
dc.rights.license http://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.contributor.institution Univ Estadual Paulista
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Estadual Paulista, Fac Ciencias Farmaceut, Dept Alimentos & Nutr, BR-14802901 São Paulo, Brazil
dc.description.affiliation Univ Estadual Paulista, Dept Anal Clin, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Educ Fis & Motricidade Humana, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Biociencias, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Educ Fis & Motricidade Humana, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Biociencias, São Paulo, Brazil
dc.identifier.doi 10.1007/s00217-008-0883-1
dc.description.source Web of Science
dc.identifier.wos WOS:000259189800003



Arquivos deste item

Arquivos Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item aparece na(s) seguinte(s) coleção(s)

Mostrar registro simples