Fluctuation of annexin-A1 positive mast cells in chronic granulomatous inflammation

Fluctuation of annexin-A1 positive mast cells in chronic granulomatous inflammation

Autor Oliani, S. M. Autor UNIFESP Google Scholar
Ciocca, G. A. Panin Google Scholar
Pimentel, T. A. Autor UNIFESP Google Scholar
Damazo, Amilcar Sabino Autor UNIFESP Google Scholar
Gibbs, L. Google Scholar
Perretti, M. Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
William Harvey Res Inst
Resumo Objective: We have applied here a model of chronic granulomatous inflammation to study the profile of mast cell activation and their expression of annexin-A1 in the nodular lesion.Materials: Granulomatous inflammation was induced by injection of croton oil and Freund's complete adjuvant (CO/FCA) into the dorsal air-pouches of mice. Skin tissue samples were collected from control group (24 h time-point; i.e. before disease development) and 7, 14, 21, 28 and 42 days post-CO/FCA treatment.Results: Histopathological analyses revealed an on-going inflammation characterized by an increased number of activated mast cells at sites of the chronic inflammatory reaction in all experimental groups. Immunohistochemical analysis showed skin mast cells highly immunoreactive for annexin-A1, both at an initial (day 7) and a delayed (day 28) phase of the inflammatory reaction.Conclusions: the observed time-dependent modulation of mast cell activation, during the granulomatous injury, indicates that multiple pathways centred on annexin-A1 might become activated at different stages of this chronic inflammatory response, including the delayed and pro-resolving phase.
Palavra-chave Lipocortin 1
Mast cell
Air-pouch model
Skin
Neutrophil
Granuloma
Idioma Inglês
Data de publicação 2008-10-01
Publicado em Inflammation Research. Basel: Birkhauser Verlag Ag, v. 57, n. 10, p. 450-456, 2008.
ISSN 1023-3830 (Sherpa/Romeo, fator de impacto)
Publicador Birkhauser Verlag Ag
Extensão 450-456
Fonte http://dx.doi.org/10.1007/s00011-008-7222-7
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000261984800002
Endereço permanente http://repositorio.unifesp.br/handle/11600/30932

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