Antimicrobial activity of DC-159a, a new fluoroquinolone, against 1,149 recently collected clinical isolates

Antimicrobial activity of DC-159a, a new fluoroquinolone, against 1,149 recently collected clinical isolates

Author Jones, Ronald N. Google Scholar
Fritsche, Thomas R. Google Scholar
Sader, Helio S. Autor UNIFESP Google Scholar
Institution JMI Labs
Tufts Univ
Universidade Federal de São Paulo (UNIFESP)
Abstract The activity of DC-159a, a novel orally administered fluorinated quinolone, was evaluated by reference broth microdilution or agar dilution methods against 1,149 recently collected clinical isolates from five continents. Against pathogens associated with community-acquired respiratory tract infections (CA-RTIs), the MIC(90)s were 0.12 mu g/ml for Streptococcus pneumoniae, 0.015 to 0.03 mu g/ml for Haemophilus influenzae, 0.03 mu g/ml for Moraxella catarrhalis, and 0.12 mu g/ml for beta-hemolytic streptococci. Similarly, DC-59a was potent against various types of staphylococci (MIC90 range, 0.03 to 2 mu g/ml), Enterococcus faecalis (MIC90, 4 mu g/ml), wild-type isolates of the family Enterobacteriaceae (MIC90 range, 0.06 to 2 mu g/ml), wild-type Pseudomonas aeruginosa (MIC90, 2 mu g/ml), and Acinetobacter spp. (MIC90, 0.12 mu g/ml). Fluoroquinolone-nonsusceptible organism subsets usually had elevated DC-159a MICs, but the MICs were often two- to fourfold lower than those of levofloxacin and moxifloxacin. in conclusion, DC-159a appears to possess a balanced broad spectrum of activity that exceeds the activities of the currently marketed fluoroquinolones, especially against pathogens that cause CA-RTIs.
Language English
Sponsor Daiichi Pharmaceutical Co., Ltd.
Date 2008-10-01
Published in Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 52, n. 10, p. 3763-3775, 2008.
ISSN 0066-4804 (Sherpa/Romeo, impact factor)
Publisher Amer Soc Microbiology
Extent 3763-3775
Origin http://dx.doi.org/10.1128/AAC.00294-08
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000259480800039
URI http://repositorio.unifesp.br/handle/11600/30921

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