The development of a rat model of erectile dysfunction after radical prostatectomy: preliminary findings

The development of a rat model of erectile dysfunction after radical prostatectomy: preliminary findings

Autor Kaufmann, Oskar Autor UNIFESP Google Scholar
Claro, Joaquim Autor UNIFESP Google Scholar
Cury, José Autor UNIFESP Google Scholar
Andrade, Enrico Autor UNIFESP Google Scholar
Longo, Beatriz Autor UNIFESP Google Scholar
Aguiar, Wilson Autor UNIFESP Google Scholar
Mello, Luiz Autor UNIFESP Google Scholar
Srougi, Miguel Autor UNIFESP Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo To develop a rat model of erectile dysfunction (ED) after cavernous nerve injury.Given the great similarity between the anatomical structure of the cavernous nerve in rats and humans, 24 rats underwent dissections and the cavernous nerves were identified with the aid of an operating microscope. Then the rats were randomized into two groups: sham-operated controls and a bilateral cavernous nerve section group. At 3 months after surgery, the rats were evaluated for their response to an apomorphine challenge.The erectile response after an apomorphine challenge was normal in all the control rats, while there were no erections in the bilateral injured group.The rat major autonomic ganglion and its cavernous nerve can be identified with the aid of a microscope. Rats are inexpensive and easy to handle, thus a good animal for developing an ED model of cavernous nerve injury. in the present study, the rats with cavernous nerve injury lost erectile capacity in a reliable and reproducible fashion. Because of the great similarity between the cavernous nerve of rats and humans, one may consider this technique as a reliable experimental model for studying ED after radical prostatectomy.
Assunto erectile dysfunction
animal model
cavernous nerve
Idioma Inglês
Financiador Institutos do Milenio de Bioengenharia Tecidual
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Data 2008-10-01
Publicado em Bju International. Malden: Wiley-Blackwell, v. 102, n. 8, p. 1026-1028, 2008.
ISSN 1464-4096 (Sherpa/Romeo, fator de impacto)
Editor Wiley-Blackwell
Extensão 1026-1028
Fonte http://dx.doi.org/10.1111/j.1464-410X.2008.07760.x
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000259360100020
URI http://repositorio.unifesp.br/handle/11600/30920

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