Coccidioidal pericarditis: a rapid presumptive diagnosis by an in-house antigen confirmed by mycological and molecular methods

Coccidioidal pericarditis: a rapid presumptive diagnosis by an in-house antigen confirmed by mycological and molecular methods

Autor Brilhante, Raimunda S. N. Google Scholar
Cordeiro, Rossana A. Google Scholar
Rocha, Marcos F. G. Google Scholar
Fechine, Maria A. B. Google Scholar
Furtado, Felipe M. Google Scholar
Nagao-Dias, Aparecida T. Google Scholar
Camargo, Zoilo P. Autor UNIFESP Google Scholar
Sidrim, Jose J. C. Google Scholar
Instituição Univ Fed Ceara
Univ Estadual Ceara
Universidade Federal de São Paulo (UNIFESP)
Resumo Coccidioidal pericarditis is a condition found in approximately 1-5% of patients infected by Coccidioides species. It is associated with widely diverse clinical symptoms. This paper reports a case of coccidioidal pericarditis diagnosed by an in-house Coccidioides posadasii antigen and confirmed with mycological and molecular methods. From February to September 2005, the patient suffered from fever, weight loss, a non-productive cough, thoracic pain and tachycardia. He received a positive diagnosis of coccidioidal pericarditis only in October 2005. the macromorphological examination of the culture showed a whitish felt-like colony, which became brownish with age. Preparations in lactophenol cotton blue stain showed hyaline septate hyphae with fragmentation and thin arthroconidia-like structures. Pericardial fluid and sera samples were positive for Coccidioides antibodies by immunodiffusion and ELISA with a C. posadasii in-house antigen preparation. the C. posadasii identification was confirmed by nested PCR of the antigen 2/proline-rich antigen (Ag2/PRA) encoding gene.
Idioma Inglês
Financiador Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Número do financiamento CNPq: 150984/2005-7
CNPq: 620161/2006-0
FAPESP: 4/14270-0
Data de publicação 2008-10-01
Publicado em Journal of Medical Microbiology. Reading: Soc General Microbiology, v. 57, n. 10, p. 1288-1292, 2008.
ISSN 0022-2615 (Sherpa/Romeo, fator de impacto)
Publicador Soc General Microbiology
Extensão 1288-1292
Fonte http://dx.doi.org/10.1099/jmm.0.2008/002428-0
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000259950400017
Endereço permanente http://repositorio.unifesp.br/handle/11600/30916

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