Haloperidol (but not ziprasidone) withdrawal potentiates sensitization to the hyperlocomotor effect of cocaine in mice

Haloperidol (but not ziprasidone) withdrawal potentiates sensitization to the hyperlocomotor effect of cocaine in mice

Autor Fukushiro, Daniela Fukue Autor UNIFESP Google Scholar
Carvalho, Rita de Cassia Autor UNIFESP Google Scholar
Ricardo, Victor Proenca Autor UNIFESP Google Scholar
Alvarez, Juliana do Nascimento Autor UNIFESP Google Scholar
Carvalho Ribeiro, Luciana Takahashi Autor UNIFESP Google Scholar
Frussa-Filho, Roberto Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo One important contributing factor in the high prevalence of drug abuse disorders seen among schizophrenic patients seems to be related to chronic treatment with typical neuroleptics. We have previously demonstrated that withdrawal from long-term treatment with the typical neuroleptic haloperidol, but not the atypical neuroleptic ziprasidone, potentiated the hyperlocomotor effect induced by a single cocaine injection and cocaine-induced conditioned place preference in mice. in the present study we investigated whether withdrawal from long-term treatment with these same neuroleptics would also modify cocaine-induced hyperlocomotion sensitization, which has been proposed as an animal model for the intensification of drug craving in cocaine addiction. Swiss male mice were i.p. treated with haloperidol (1.0 mg/kg) or ziprasidone (4.0 mg/kg) for 15 days. Twenty-four hours after the last injection, animals received an i.p. injection of cocaine (10 mg/kg) for 5 consecutive days, being placed after each injection in the open-field apparatus in order to perform a drug-environment conditioning. Seven days after the last drug-environment conditioning procedure, the animals were challenged with an i.p. injection of cocaine (10 mg/kg), placed in the open-field apparatus and had their locomotor activity quantified. Withdrawal from haloperidol (but not ziprasidone) potentiated cocaine-induced behavioral sensitization. These results are suggested to be a consequence of the development of the dopaminergic supersensitivity phenomenon by long-term treatment with the typical compound. Our findings provide additional support for the use of atypical agents like ziprasidone in the treatment of schizophrenic patients with comorbid substance abuse disorder. (C) 2008 Elsevier Inc. All rights reserved.
Palavra-chave cocaine-induced behavioral sensitization
dopaminergic supersensitivity
haloperidol
ziprasidone
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundacao Coordenacao de Aperfeicoamento de Pessoal de Nivel
Data de publicação 2008-09-30
Publicado em Brain Research Bulletin. Oxford: Pergamon-Elsevier B.V., v. 77, n. 2-3, p. 124-128, 2008.
ISSN 0361-9230 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 124-128
Fonte http://dx.doi.org/10.1016/j.brainresbull.2008.05.004
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000259552900009
Endereço permanente http://repositorio.unifesp.br/handle/11600/30910

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta