Anti-Plasmodium Activity of Angiotensin II and Related Synthetic Peptides

Anti-Plasmodium Activity of Angiotensin II and Related Synthetic Peptides

Autor Maciel, Ceres Google Scholar
Oliveira Junior, Vani Xavier de Google Scholar
Fazio, Marcos Antonio Autor UNIFESP Google Scholar
Nacif-Pimenta, Rafael Google Scholar
Miranda, Antonio Autor UNIFESP Google Scholar
Pimenta, Paulo F. P. Google Scholar
Capurro, Margareth Lara Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal do ABC (UFABC)
Universidade Federal de São Paulo (UNIFESP)
Fundacao Oswaldo Cruz
Resumo Plasmodium species are the causative agents of malaria, the most devastating insect-borne parasite of human populations. Finding and developing new drugs for malaria treatment and prevention is the goal of much research. Angiotensins I and II (ang I and ang II) and six synthetic related peptides designated Vaniceres 1-6 (VC1-VC6) were assayed in vivo and in vitro for their effects on the development of the avian parasite, Plasmodium gallinaceum. Ang II and VC5 injected into the thoraces of the insects reduced mean intensities of infection in the mosquito salivary glands by 88% and 76%, respectively. Although the mechanism(s) of action is not completely understood, we have demonstrated that these peptides disrupt selectively the P. gallinaceum cell membrane. Additionally, incubation in vitro of sporozoites with VC5 reduced the infectivity of the parasites to their vertebrate host. VC5 has no observable agonist effects on vertebrates, and this makes it a promising drug for malaria prevention and chemotherapy.
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Número do financiamento CNPq: fellows
Data 2008-09-29
Publicado em Plos One. San Francisco: Public Library Science, v. 3, n. 9, 8 p., 2008.
ISSN 1932-6203 (Sherpa/Romeo, fator de impacto)
Editor Public Library Science
Extensão 8
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000264432500006

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