Anticonvulsant effect of a natural compound alpha,beta-epoxy-carvone and its action on the nerve excitability

Anticonvulsant effect of a natural compound alpha,beta-epoxy-carvone and its action on the nerve excitability

Autor Almeida, Reinaldo Nobrega de Google Scholar
Sousa, Damiao Pergentino de Google Scholar
Farias Nobrega, Franklin Ferreira de Google Scholar
Claudino, Fladmir de Sousa Google Scholar
Machado Araujo, Demetrius Antonio Google Scholar
Leite, Jose Roberto Autor UNIFESP Google Scholar
Mattei, Rita Autor UNIFESP Google Scholar
Instituição Univ Fed Sergipe
Univ Fed Paraiba
Universidade Federal de São Paulo (UNIFESP)
Resumo The anticonvulsant effect of alpha,beta-epoxy-carvone (EC), a monoterpene monocyclic, was investigated in three animal models. EC at 300 or 400 mg/kg promoted protection of 75% and 87.5%. respectively, against convulsions induced chemically by pentylenetetrazole (PTZ) and it was efficient in prevents the tonic convulsions induced by maximal electroshock (MES) in doses of 200, 300 or 400 mg/kg, resulting in 25%, 25% and 100% of protection, respectively. This monoterpene was also capable to promote an increase of latency for development of convulsions induced by picrotoxin (PIC) at 300 or 400 mg/kg and presented a significant protection against convulsions at doses of 200, 300 or 400 mg/kg, resulting in 12.5%, 12.5% and 100% of protection, respectively. On the other hand, the anticonvulsant effect of EC, was not affected by pretreatment with flumazenil (FLU), a selective antagonist of benzodiazepine site of GABA(A) receptor. Additionally was observed that EC treatment reduced the levels of in vitro lipoperoxidation and decreased (21.2%) the amplitude of compound action potential after 30 min of incubation. the present results clearly indicate the ability of EC to modulate the anticonvulsant and antioxidant effects. However, our data suggests that the action mechanisms are not due a direct activation of the GABAA benzodiazepine receptors, but could be associated with the reduction of isolated nerve excitability, possibly involving a voltage-gated Na(+) channels blockade. Crown Copyright (C) 2008 Published by Elsevier Ireland Ltd. All rights reserved.
Palavra-chave anticonvulsant activity
essential oils
monoterpene
epilepsy
isolated nerve
compound action potential
antioxidant
Idioma Inglês
Financiador Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundacao de Apoio a Pesquisa do Estado da Paraiba (FAPESQ-PB)
Associacao Fundo de Incentivo a Psicofarmacologia (AFIP)
Data de publicação 2008-09-26
Publicado em Neuroscience Letters. Clare: Elsevier B.V., v. 443, n. 1, p. 51-55, 2008.
ISSN 0304-3940 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 51-55
Fonte http://dx.doi.org/10.1016/j.neulet.2008.07.037
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000259312600011
Endereço permanente http://repositorio.unifesp.br/handle/11600/30908

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