TNF-alpha polymorphisms are associated with obsessive-compulsive disorder

TNF-alpha polymorphisms are associated with obsessive-compulsive disorder

Autor Hounie, Ana Gabriela Google Scholar
Cappi, Carolina Google Scholar
Cordeiro, Quirino Google Scholar
Sampaio, Aline Santos Google Scholar
Moraes, Ivanil Google Scholar
Rosario, Maria Conceicao do Autor UNIFESP Google Scholar
Palacios, Selma A. Google Scholar
Goldberg, Anna Carla Google Scholar
Vallada, Homero Pinto Google Scholar
Machado-Lima, Ariane Google Scholar
Nakano, Eduardo Google Scholar
Kalil, Jorge Google Scholar
Pauls, David Google Scholar
Pereira, Carlos Alberto B. Google Scholar
Guilherme, Luiza Google Scholar
Miguel, Euripedes Constantino Google Scholar
Instituição Universidade de São Paulo (USP)
Harvard Univ
Universidade Federal de São Paulo (UNIFESP)
Resumo Introduction: Several lines of evidence support an immunologic involvement in obsessive-compulsive disorder (OCD): the increased prevalence of OCD in patients with rheumatic fever (RF), and the aggregation of obsessive-compulsive spectrum disorders among relatives of RF probands. Tumor necrosis factor alpha is a proinflammatory cytokine involved in RF and other autoimmune diseases. Polymorphisms in the promoter region of the TNFA gene have been associated with RE Given the association between OCD and RF, the goal of the present study was to investigate a possible association between polymorphisms within the promoter region of TNFA and OCD. Materials and methods: Two polymorphisms were investigated: -308 G/A and -238 G/A. the allelic and genotypic frequencies of these polymorphisms were examined in 111 patients who fulfilled DSM-IV criteria for OCD and compared with the frequencies in 250 controls. Results: Significant associations were observed between both polymorphisms and OCD. for -238 G/A, an association between the A allele and OCD was observed (X-2 = 12.05, p = 0.0005). A significant association was also observed between the A allele of the -308 G/A polymorphism and OCD (X-2 = 7.09, p = 0.007). Finally, a haplotype consisting of genotypes of these two markers was also examined. Significant association was observed for the A-A haplotype (p = 0.0099 after correcting for multiple testing). Discussion: There is association between the -308 G/A and -238 G/A TNFA polymorphisms and OCD in our Brazilian sample. However, these results need to be replicated in larger samples collected from different populations. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
Palavra-chave case-control study
cytokine
autoimmune
molecular genetics
rheumatic fever
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Número do financiamento FAPESP: 98/15-013-9
FAPESP: 2005/55628-8
Data de publicação 2008-09-12
Publicado em Neuroscience Letters. Clare: Elsevier B.V., v. 442, n. 2, p. 86-90, 2008.
ISSN 0304-3940 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 86-90
Fonte http://dx.doi.org/10.1016/j.neulet.2008.07.022
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000258909500002
Endereço permanente http://repositorio.unifesp.br/handle/11600/30905

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