Hyperbaric Oxygen Prevents Early Death Caused by Experimental Cerebral Malaria

Hyperbaric Oxygen Prevents Early Death Caused by Experimental Cerebral Malaria

Autor Blanco, Yara C. Google Scholar
Farias, Alessandro S. Google Scholar
Goelnitz, Uta Google Scholar
Lopes, Stefanie C. P. Google Scholar
Arrais-Silva, Wagner W. Google Scholar
Carvalho, Bruna O. Google Scholar
Amino, Rogerio Autor UNIFESP Google Scholar
Wunderlich, Gerhard Google Scholar
Santos, Leonilda M. B. Google Scholar
Giorgio, Selma Google Scholar
Costa, Fabio Trindade Maranhão Autor UNIFESP Google Scholar
Instituição Universidade Estadual de Campinas (UNICAMP)
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo Background: Cerebral malaria (CM) is a syndrome characterized by neurological signs, seizures and coma. Despite the fact that CM presents similarities with cerebral stroke, few studies have focused on new supportive therapies for the disease. Hyperbaric oxygen (HBO) therapy has been successfully used in patients with numerous brain disorders such as stroke, migraine and atherosclerosis.Methodology/Principal Findings: C57BL/6 mice infected with Plasmodium berghei ANKA (PbA) were exposed to daily doses of HBO (100% O(2), 3.0 ATA, 1-2 h per day) in conditions well-tolerated by humans and animals, before or after parasite establishment. Cumulative survival analyses demonstrated that HBO therapy protected 50% of PbA-infected mice and delayed CM-specific neurological signs when administrated after patent parasitemia. Pressurized oxygen therapy reduced peripheral parasitemia, expression of TNF-alpha, IFN-gamma and IL-10 mRNA levels and percentage of gamma delta and alpha beta CD4(+) and CD8(+) T lymphocytes sequestered in mice brains, thus resulting in a reduction of blood-brain barrier (BBB)dysfunction and hypothermia.Conclusions/Significance: the data presented here is the first indication that HBO treatment could be used as supportive therapy, perhaps in association with neuroprotective drugs, to prevent CM clinical outcomes, including death.
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Número do financiamento FAPESP: 2004/00638-6
Data 2008-09-04
Publicado em Plos One. San Francisco: Public Library Science, v. 3, n. 9, 10 p., 2008.
ISSN 1932-6203 (Sherpa/Romeo, fator de impacto)
Editor Public Library Science
Extensão 10
Fonte http://dx.doi.org/10.1371/journal.pone.0003126
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000264419100001
URI http://repositorio.unifesp.br/handle/11600/30902

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