Therapeutic use of Cannabis sativa on chemotherapy-induced nausea and vomiting among cancer patients: systematic review and meta-analysis

Therapeutic use of Cannabis sativa on chemotherapy-induced nausea and vomiting among cancer patients: systematic review and meta-analysis

Autor Rocha, F. C. Machado Autor UNIFESP Google Scholar
Stefano, S. C. Autor UNIFESP Google Scholar
Haiek, R. de Cassia Autor UNIFESP Google Scholar
Oliveira, L. M. Q. Rosa Google Scholar
Da Silveira, D. X. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo This paper aims to evaluate the anti-emetic efficacy of cannabinoids in cancer patients receiving chemotherapy using a systematic review of literature searched within electronic databases such as PUBMED, EMBASE, PSYCINFO, LILACS, and 'The Cochrane Collaboration Controlled Trials Register'. Studies chosen were randomized clinical trials comprising all publications of each database until December 2006. From 12 749 initially identified papers, 30 fulfilled the inclusion criteria for this review, with demonstration of superiority of the anti-emetic efficacy of cannabinoids compared with conventional drugs and placebo. the adverse effects were more intense and occurred more often among patients who used cannabinoids. Five meta-analyses were carried out: (1) dronabinol versus placebo [n = 185; relative risk (RR) = 0.47; confidence interval (CI) = 0.19-1.16]; (2) Dronabinol versus neuroleptics [n = 325; RR = 0.67; CI = 0.47-0.96; number needed to treat (NNT) = 3.4]; (3) nabilone versus neuroleptics (n = 277; RR = 0.88; CI = 0.72-1.08); (4) levonantradol versus neuroleptics (n = 194; RR = 0.94; CI = 0.75-1.18); and (5) patients' preference for cannabis or other drugs (n = 1138; RR = 0.33; CI = 0.24-0.44; NNT = 1.8). the superiority of the anti-emetic efficacy of cannabinoids was demonstrated through meta-analysis.
Palavra-chave cancer
cannabis
chemotherapy
meta-analysis
randomized clinical trial
systematic review
Idioma Inglês
Data de publicação 2008-09-01
Publicado em European Journal of Cancer Care. Malden: Wiley-Blackwell, v. 17, n. 5, p. 431-443, 2008.
ISSN 0961-5423 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 431-443
Fonte http://dx.doi.org/10.1111/j.1365-2354.2008.00917.x
Direito de acesso Acesso restrito
Tipo Resenha
Web of Science WOS:000258728600002
Endereço permanente http://repositorio.unifesp.br/handle/11600/30894

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