Preliminary investigation of the central nervous system effects of 'Tira-capeta' (Removing the Devil), a cigarette used by some Quilombolas living in Pantanal Wetlands of Brazil

Preliminary investigation of the central nervous system effects of 'Tira-capeta' (Removing the Devil), a cigarette used by some Quilombolas living in Pantanal Wetlands of Brazil

Autor Rodrigues, Eliana Autor UNIFESP Google Scholar
Gianfratti, Bruno Autor UNIFESP Google Scholar
Tabach, Ricardo Autor UNIFESP Google Scholar
Negri, Giuseppina Autor UNIFESP Google Scholar
Mendes, Fulvio R. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo During an ethnopharmacological survey carried out among some Quilombolas living in Brazil, 48 plants with possible central nervous system (CNS) action were cited. A mixture of nine plants, known as 'Tira-capeta' (Removing the Devil) cigarette, has been utilized for years as a tonic for the brain. the effects observed after consuming this cigarette are: dizziness, lightness sensation, humor changes, yawns, heavy eyes, hunger, sleep and relaxation. This study aimed to verify the effects of a hydroalcohol extract of 'Tira-capeta' cigarette (ETC), as well as to evaluate the phytochemical profile. the phytochemical screening carried out through characterization reactions, thin layer chromatography and high efficiency liquid chromatography indicated the presence of tannins, phenolic acids, flavonoids, saponins and alkaloids; tannins and phenolic acids being the principal constituents. the pharmacological tests showed that ETC induced a biphasic effect, with intense initial stimulation of the CNS, followed by a general depressor state; decreased the latency for sleeping and increased the total sleeping time (50, 100 and 500 mg/kg), without causing prejudice in motor coordination (doses tip to 200 mg/kg); induced catalepsy in mice, verified 10 and 50 min after drug administration (500 mg/kg). Also, no anxiolytic or anxiogenic effects were verified in rats submitted to the elevated plus-maze. Copyright (c) 2008 John Wiley & Sons, Ltd.
Palavra-chave ethnopharmacology
Quilombolas
neuroleptic smoke
central nervous system
medicinal plants
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Associacao Fundo de Incentivo a Psicofarmacologia (AFIP)
Data de publicação 2008-09-01
Publicado em Phytotherapy Research. Chichester: John Wiley & Sons Ltd, v. 22, n. 9, p. 1248-1255, 2008.
ISSN 0951-418X (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 1248-1255
Fonte http://dx.doi.org/10.1002/ptr.2474
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000259625800020
Endereço permanente http://repositorio.unifesp.br/handle/11600/30876

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