Genome Sequence of a Lancefield Group C Streptococcus zooepidemicus Strain Causing Epidemic Nephritis: New Information about an Old Disease

Genome Sequence of a Lancefield Group C Streptococcus zooepidemicus Strain Causing Epidemic Nephritis: New Information about an Old Disease

Autor Beres, Stephen B. Google Scholar
Sesso, Ricardo Autor UNIFESP Google Scholar
Pinto, Sergio Wyton L. Google Scholar
Hoe, Nancy P. Google Scholar
Porcella, Stephen F. Google Scholar
Deleo, Frank R. Google Scholar
Musser, James M. Google Scholar
Instituição Methodist Hosp
Universidade Federal de São Paulo (UNIFESP)
Hosp Sao Joao Deus
Resumo Outbreaks of disease attributable to human error or natural causes can provide unique opportunities to gain new information about host-pathogen interactions and new leads for pathogenesis research. Poststreptococcal glomerulonephritis (PSGN), a sequela of infection with pathogenic streptococci, is a common cause of preventable kidney disease worldwide. Although PSGN usually occurs after infection with group A streptococci, organisms of Lancefield group C and G also can be responsible. Despite decades of study, the molecular pathogenesis of PSGN is poorly understood. As a first step toward gaining new information about PSGN pathogenesis, we sequenced the genome of Streptococcus equi subsp. zooepidemicus strain MGCS10565, a group C organism that caused a very large and unusually severe epidemic of nephritis in Brazil. the genome is a circular chromosome of 2,024,171 bp. the genome shares extensive gene content, including many virulence factors, with genetically related group A streptococci, but unexpectedly lacks prophages. the genome contains many apparently foreign genes interspersed around the chromosome, consistent with the presence of a full array of genes required for natural competence. An inordinately large family of genes encodes secreted extracellular collagen-like proteins with multiple integrin-binding motifs. the absence of a gene related to speB rules out the long-held belief that streptococcal pyrogenic exotoxin B or antibodies reacting with it singularly cause PSGN. Many proteins previously implicated in GAS PSGN, such as streptokinase, are either highly divergent in strain MGCS10565 or are not more closely related between these species than to orthologs present in other streptococci that do not commonly cause PSGN. Our analysis provides a comparative genomics framework for renewed appraisal of molecular events underlying APSGN pathogenesis.
Idioma Inglês
Financiador National Institute of Allergy and Infectious Diseases
Número do financiamento National Institute of Allergy and Infectious Diseases: UO1-60595
Data 2008-08-21
Publicado em Plos One. San Francisco: Public Library Science, v. 3, n. 8, 16 p., 2008.
ISSN 1932-6203 (Sherpa/Romeo, fator de impacto)
Editor Public Library Science
Extensão 16
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000264426800005

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