Centromeres in cell division, evolution, nuclear organization and disease

Centromeres in cell division, evolution, nuclear organization and disease

Autor Santos Silva, Amanda Goncalves dos Autor UNIFESP Google Scholar
Sarkar, Rahul Google Scholar
Harizanova, Jana Google Scholar
Guffei, Amanda Google Scholar
Mowat, Michael Google Scholar
Garini, Yuval Google Scholar
Mai, Sabine Google Scholar
Instituição Univ Manitoba
Universidade Federal de São Paulo (UNIFESP)
Sunnybrook Hlth Sci Ctr
Bar Ilan Univ
Resumo As the spindle fiber attachment region of the chromosome, the centromere has been investigated in a variety of contexts. Here, we will review current knowledge about this unique chromosomal region and its relevance for proper cell division, speciation, and disease. Understanding the three-dimensional organization of centromeres in normal and turner cells is just beginning to emerge. Multidisciplinary research will allow for new insights into its normal and aberrant nuclear organization and may allow for new therapeutic interventions that target events linked to centromere function and cell division.
Palavra-chave centromere
cell division
evolution
cancer
3D nucleus
imaging
Idioma Inglês
Data de publicação 2008-08-15
Publicado em Journal of Cellular Biochemistry. Hoboken: Wiley-Blackwell, v. 104, n. 6, p. 2040-2058, 2008.
ISSN 0730-2312 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 2040-2058
Fonte http://dx.doi.org/10.1002/jcb.21766
Direito de acesso Acesso restrito
Tipo Resenha
Web of Science WOS:000258387200009
Endereço permanente http://repositorio.unifesp.br/handle/11600/30852

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