Centromeres in cell division, evolution, nuclear organization and disease

Centromeres in cell division, evolution, nuclear organization and disease

Author Santos Silva, Amanda Goncalves dos Autor UNIFESP Google Scholar
Sarkar, Rahul Google Scholar
Harizanova, Jana Google Scholar
Guffei, Amanda Google Scholar
Mowat, Michael Google Scholar
Garini, Yuval Google Scholar
Mai, Sabine Google Scholar
Institution Univ Manitoba
Universidade Federal de São Paulo (UNIFESP)
Sunnybrook Hlth Sci Ctr
Bar Ilan Univ
Abstract As the spindle fiber attachment region of the chromosome, the centromere has been investigated in a variety of contexts. Here, we will review current knowledge about this unique chromosomal region and its relevance for proper cell division, speciation, and disease. Understanding the three-dimensional organization of centromeres in normal and turner cells is just beginning to emerge. Multidisciplinary research will allow for new insights into its normal and aberrant nuclear organization and may allow for new therapeutic interventions that target events linked to centromere function and cell division.
Keywords centromere
cell division
evolution
cancer
3D nucleus
imaging
Language English
Date 2008-08-15
Published in Journal of Cellular Biochemistry. Hoboken: Wiley-Blackwell, v. 104, n. 6, p. 2040-2058, 2008.
ISSN 0730-2312 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 2040-2058
Origin http://dx.doi.org/10.1002/jcb.21766
Access rights Closed access
Type Review
Web of Science ID WOS:000258387200009
URI http://repositorio.unifesp.br/handle/11600/30852

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