Loss of neuronal projections in the dystrophin-deficient mdx mouse is not progressive

Loss of neuronal projections in the dystrophin-deficient mdx mouse is not progressive

Autor Pinto, Magali Luci Autor UNIFESP Google Scholar
Olyntho Tokunaga, Heloisa Helena Vieira Autor UNIFESP Google Scholar
Souccar, Caden Autor UNIFESP Google Scholar
Schoorlemmer, Gerhardus Hermanus Maria Autor UNIFESP Google Scholar
Ribeiro da Silva Lapa, Rita de Cassia Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Lack of dystrophin is known to reduce several cerebral fiber systems. To investigate if the loss of fibers is progressive, we analyzed projections of the trigeminal sensory system to the red nucleus in 3, 6, and 12 month old dystrophin-deficient mdx mice. the retrograde tracer fluorogold was injected in the magnocellular part of the red nucleus, and the number of labeled neurons in the oral part of the spinal trigeminal nucleus (Sp5O) was counted. we found that the number of labeled Sp5O neurons was reduced by 50% in mdx mice compared to age-matched control mice. the number of labeled Sp5O neurons did not change significantly between 3 and 12 months neither in mdx nor in control mice. in addition, the number of labeled neurons in the interstitial system of the trigeminal nerve was reduced by 43% in mdx mice. We conclude that fiber loss did not continue beyond the age of 3 months. Our data suggest that lack of full-length dystrophin impairs neuronal migration or axonal outgrowth, or increases neuronal death during fetal or early life. (c) 2008 Elsevier B.V. All rights reserved.
Assunto dystrophin
neuronal loss
Duchenne's muscular dystrophy
red nucleus
trigeminal sensory complex
aging
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Número do financiamento FAPESP: 99/06625-3
Data 2008-08-11
Publicado em Brain Research. Amsterdam: Elsevier B.V., v. 1224, p. 127-132, 2008.
ISSN 0006-8993 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 127-132
Fonte http://dx.doi.org/10.1016/j.brainres.2008.05.059
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000259060300014
URI http://repositorio.unifesp.br/handle/11600/30849

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